Feasibility and safety of lumbar puncture in the Parkinson's disease research participants: Parkinson's Progression Marker Initiative (PPMI)

Neha Prakash¹, Chelsea Caspell-Garcia², Christopher Coffey³, Andrew Siderowf⁴, Caroline M Tanner⁵, Karl Kieburtz⁶, Brit Mollenhauer⁷, Douglas Galasko⁸, Kalpana Merchant⁹, Tatiana Foroud¹⁰, Lana M Chahine¹¹, Daniel Weintraub¹², Cindy Casaceli¹³, Ray Dorsey¹⁴, Renee Wilson¹⁵, Margaret Herzog¹⁶, Nichole Daegele¹⁷, Vanessa Arnedo¹⁸, Mark Frasier¹⁹, Todd Sherer²⁰, Ken Marek²¹, Samuel Frank²², Danna Jennings²³, Tanya Simuni²⁴; Parkinson's Progression Markers InitiativeSteering Committee; Study Cores; Site Investigators; Coordinators; Industry and Scientific Advisory Board

Collaborators, Affiliations

Collaborators

Kenneth Marek²⁵, Andrew Siderowf²⁶, John Seibyl²⁵, Christopher Coffey²⁷, Caroline Tanner²⁸, Duygu Tosun-Turgut²⁸, Tanya Simuni²⁹, Leslie Shaw²⁶, John Trojanowski²⁶, Andrew Singleton³⁰, Karl Kieburtz³¹, Arthur Toga³², Brit Mollenhauer³¹, Douglas Galasko³³, Werner Poewe³⁴, Tatiana Foroud³⁵, Kathleen Poston³⁶, Todd Sherer³⁷, Sohini Chowdhury³⁷, Mark Frasier³⁷, Catherine Kopil³⁷, Vanessa Arnedo³⁷, Kenneth Marek²⁵, Nichole Daegele²⁵, Cynthia Casaceli³⁸, Ray Dorsey³⁸, Renee Wilson³⁸, Sugi Mahes³⁸, John Seibyl²⁵, Christina Salerno²⁵, Christopher Coffey²⁷, Chelsea Caspell-Garcia²⁷, Arthur Toga³², Karen Crawford³², Tatiana Foroud³⁵, Paola Casalin³⁹, Giulia Malferrari³⁹, Mali Gani Weisz⁴⁰, Avi Orr-Urtreger⁴⁰, John Trojanowski²⁶, Leslie Shaw²⁶, Andrew Singleton³⁰, Tatiana Foroud³⁵, Tatiana Foroud³⁵, Thomas Montine³⁶, Tatiana Foroud³⁵, David Russell²⁵, Caroline Tanner²⁸, Tanya Simuni²⁹, Nabila Dahodwala²⁶, Brit Mollenhauer³¹, Douglas Galasko³³, Werner Poewe³⁴, Nir Giladi⁴⁰, Stewart Factor⁴¹, Penelope Hogarth⁴², David Standaert⁴³, Robert Hauser⁴⁴, Joseph Jankovic⁴⁵, Marie Saint-Hilaire⁴⁶, Irene Richard⁴⁷, David Shprecher⁴⁸, Hubert Fernandez⁴⁹, Katrina Brockmann⁵⁰, Liana Rosenthal⁵¹, Paolo Barone⁵², Alberto Espay⁵³, Dominic Rowe⁵⁴, Karen Marder⁵⁵, Anthony Santiago⁵⁶, Susan Bressman⁵⁷, Shu-Ching Hu⁵⁸, Stuart Isaacson⁵⁹, Jean-Christophe Corvol⁶⁰, Javiar Ruiz Martinez⁶¹, Eduardo Tolosa⁶², Yen Tai⁶³, Marios Politis⁶⁴, Debra Smejdir²⁵, Linda Rees²⁵, Karen Williams²⁷, Farah Kausar²⁸, Karen Williams²⁹, Whitney Richardson²⁶, Diana Willeke³¹, Shawnees Peacock³³, Beatrice Heim³⁴, Anat Mirelman⁴⁰, Barbara Sommerfeld⁴¹, Alison Freed⁴², Katrina Wakeman⁴², Courtney Blair⁴³, Stephanie Guthrie⁴⁵, Leigh Harrell⁴⁴, Christine Hunter⁴⁵, Cathi-Ann Thomas⁴⁶, Raymond James⁴⁶, Grace Zimmerman⁴⁷, Victoria Brown⁴⁸, Jennifer Mule⁴⁹, Ella Hilt⁵⁰, Kori Ribb⁵¹, Susan Ainscough⁵², Misty Wethington⁵³, Madelaine Ranola⁵⁴, Helen Mejia Santana⁵⁵, Juliana Moreno⁵⁶, Deborah Raymond⁵⁷, Krista Speketer⁵⁸, Lisbeth Carvajal⁵⁹, Stephanie Carvalho⁶⁰, Ioana Croitoru⁶¹, Alicia Garrido⁶², Laura Marie Payne⁶³, Veena Viswanth⁶⁵, Lawrence Severt⁶⁵, Maurizio Facheris⁶⁶, Holly Soares⁶⁶, Mark A Mintun⁶⁷, Jesse Cedarbaum⁶⁸, Peggy Taylor⁶⁹, Kevin Biglan⁷⁰, Emily Vandenbroucke⁷¹, Zulfiqar Haider Sheikh⁷¹, Baris Bingol⁷², Tanya Fischer⁷³, Pablo Sardi⁷³, Remi Forrat⁷³, Alastair Reith⁷⁴, Jan Egebjerg⁷⁵, Gabrielle Ahlberg Hillert⁷⁵, Barbara Saba⁷⁶, Chris Min⁷⁷, Robert Umek⁷⁸, Joe Mather⁷⁹, Susan De Santi⁸⁰, Anke Post⁸¹, Frank Boess⁸¹, Kirsten Taylor⁸¹, Igor Grachev⁸², Andreja Avbersek⁸³, Pierandrea Muglia⁸³, Kaplana Merchant⁸⁴, Johannes Tauscher⁸⁵

Affiliations

¹ Northwestern University Feinberg School of Medicine, USA. Electronic address: neha.prakash@northwestern.edu.
² The University of Iowa, USA. Electronic address: chelsea-caspell@uiowa.edu.
³ The University of Iowa, USA. Electronic address: christopher-coffey@uiowa.edu.
⁴ The University of Pennsylvania, USA. Electronic address: Andrew.siderowf@uphs.upenn.edu.
⁵ University of California San Francisco, USA. Electronic address: caroline.tanner@ucsf.edu.
⁶ University of Rochester Medical Center, USA. Electronic address: karl.kieburtz@chet.rochester.edu.
⁷ Center of Parkinsonism and Movement Disorders Paracelsus-Elena Klinik Kassel and University Medical Center Goettingen, Germany. Electronic address: brit.mollenhauer@med.uni-goettingen.de.
⁸ University of California San Diego, USA. Electronic address: dgalasko@ucsd.edu.
⁹ TransThera Consulting, USA. Electronic address: merchant.transthera@gmail.com.
¹⁰ Indiana University, USA. Electronic address: tforoud@iu.edu.
¹¹ University of Pittsburgh, USA. Electronic address: lanachahine@pitt.edu.
¹² The University of Pennsylvania, USA. Electronic address: daniel.weintraub@uphs.penn.edu.
¹³ University of Rochester Medical Center, USA. Electronic address: cindy.casaceli@chet.rochester.edu.
¹⁴ University of Rochester Medical Center, USA. Electronic address: ray.dorsey@chet.rochester.edu.
¹⁵ Clinical Trial Coordination Center, University of Rochester Medical Center, USA. Electronic address: renee.wilson@chet.rochester.edu.
¹⁶ Michael J Fox Foundation, USA.
¹⁷ Institute for Neurodegenerative Disorders, USA. Electronic address: ndaegele@invicro.com.
¹⁸ Michael J Fox Foundation, USA. Electronic address: varnedo@michaeljfox.org.
¹⁹ Michael J Fox Foundation, USA. Electronic address: mfrasier@michaeljfox.org.
²⁰ Michael J Fox Foundation, USA. Electronic address: tsherer@michaeljfox.org.
²¹ Institute for Neurodegenerative Disorders, USA. Electronic address: kmarek@mnimaging.com.
²² Harvard Medical School, Beth Israel Deaconess Medical Center, Parkinson's Disease and Movement Disorders Center, Director of the HDSA Center of Excellence, USA. Electronic address: sfrank2@bidmc.harvard.edu.
²³ Denali Therapeutics, USA. Electronic address: jennings@dnli.com.
²⁴ Northwestern University Feinberg School of Medicine, USA. Electronic address: tsimuni@nmff.org.
²⁵ Institute for Neurodegenerative Disorders, New Haven, CT, USA.
²⁶ University of Pennsylvania, Philadelphia, PA, USA.
²⁷ University of Iowa, Iowa City, IA, USA.
²⁸ University of California, San Francisco, CA, USA.
²⁹ Northwestern University, Chicago, IL, USA.
³⁰ National Institute on Aging, NIH, Bethesda, MD, USA.
³¹ Paracelsus-Elena Klinik, Kassel, Germany.
³² Laboratory of Neuroimaging (LONI), University of Southern California, Los Angeles, CA, USA.
³³ University of California, San Diego, CA, USA.
³⁴ Innsbruck Medical University, Innsbruck, Austria.
³⁵ Indiana University, Indianapolis, IN, USA.
³⁶ Stanford University, Stanford, CA, USA.
³⁷ The Michael J. Fox Foundation for Parkinson's Research, New York, NY, USA.
³⁸ Clinical Trials Coordination Center, University of Rochester, Rochester, NY, USA.
³⁹ BioRep, Milan, Italy.
⁴⁰ Tel Aviv Medical Center, Tel Aviv, Israel.
⁴¹ Emory University of Medicine, Atlanta, GA, USA.
⁴² Oregon Health and Science University, Portland, OR, USA.
⁴³ University of Alabama at Birmingham, Birmingham, AL, USA.
⁴⁴ University of South Florida, Tampa, FL, USA.
⁴⁵ Baylor College of Medicine, Houston, TX, USA.
⁴⁶ Boston University, Boston, MA, USA.
⁴⁷ University of Rochester, Rochester, NY, USA.
⁴⁸ Banner Research Institute, Sun City, AZ, USA.
⁴⁹ Cleveland Clinic, Cleveland, OH, USA.
⁵⁰ University of Tuebingen, Tuebingen, Germany.
⁵¹ Johns Hopkins University, Baltimore, MD, USA.
⁵² University of Salerno, Salerno, Italy.
⁵³ University of Cincinnati, Cincinnati, OH, USA.
⁵⁴ Macquarie University, Sydney, Australia.
⁵⁵ Columbia University, New York, NY, USA.
⁵⁶ The Parkinson's Institute, Sunnyvale, CA, USA.
⁵⁷ Beth Israel Medical Center, New York, NY, USA.
⁵⁸ University of Washington, Seattle, WA, USA.
⁵⁹ Parkinson's Disease and Movement Disorders Center of Boca Raton, Boca Raton, FL, USA.
⁶⁰ Hospital Pitie-Salpetriere, Paris, France.
⁶¹ Hospital Donostia, San Sebastian, Spain.
⁶² Hospital Clinic de Barcelona, Barcelona, Spain.
⁶³ Imperial College London, London, United Kingdom.
⁶⁴ King's College London, London, United Kingdom.
⁶⁵ Allergan, Dublin, Ireland.
⁶⁶ Abbvie, North Chicago, IL, USA.
⁶⁷ Avid Radiopharmaceuticals, Inc, Philadelphia, PA, USA.
⁶⁸ Biogen Idec, Cambridge, MA, USA.
⁶⁹ BioLegend, Dedham, MA, USA.
⁷⁰ Eli Lilly and Company, Indianapolis, IN, USA.
⁷¹ GE Healthcare, Princeton, NJ, USA.
⁷² Genentech, San Francisco, CA, USA.
⁷³ Genzyme Sanofi, Cambridge, MA, USA.
⁷⁴ GlaxoSmithKline, Brentford, United Kingdom.
⁷⁵ H. Lundbeck A/S, Copenhagen, Denmark.
⁷⁶ Institut de Recherches Internationales Servier, Neuilly-sur-Seine, France.
⁷⁷ Merck and Co., Kenilworth, NJ, USA.
⁷⁸ Meso Scale Diagnostics, Rockville, MD, USA.
⁷⁹ Pfizer Inc, Cambridge, MA, USA.
⁸⁰ Piramal Group, Mumbai, India.
⁸¹ F. Hoffmann-La Roche Limited, Basel, Switzerland.
⁸² Teva Pharmaceutical Industries, Petah Tikva, Israel.
⁸³ UCB Pharma, Brussel, Belgium.
⁸⁴ TransThera Consulting, Portland, OR, USA.
⁸⁵ Takeda, Osaka, Japan.

PMID: 30738748
PMCID: PMC8978879
DOI: 10.1016/j.parkreldis.2018.12.025

Observational Study

Feasibility and safety of lumbar puncture in the Parkinson's disease research participants: Parkinson's Progression Marker Initiative (PPMI)

Neha Prakash et al. Parkinsonism Relat Disord. 2019 May.

. 2019 May:62:201-209.

doi: 10.1016/j.parkreldis.2018.12.025. Epub 2019 Jan 31.

Authors

Collaborators

Kenneth Marek²⁵, Andrew Siderowf²⁶, John Seibyl²⁵, Christopher Coffey²⁷, Caroline Tanner²⁸, Duygu Tosun-Turgut²⁸, Tanya Simuni²⁹, Leslie Shaw²⁶, John Trojanowski²⁶, Andrew Singleton³⁰, Karl Kieburtz³¹, Arthur Toga³², Brit Mollenhauer³¹, Douglas Galasko³³, Werner Poewe³⁴, Tatiana Foroud³⁵, Kathleen Poston³⁶, Todd Sherer³⁷, Sohini Chowdhury³⁷, Mark Frasier³⁷, Catherine Kopil³⁷, Vanessa Arnedo³⁷, Kenneth Marek²⁵, Nichole Daegele²⁵, Cynthia Casaceli³⁸, Ray Dorsey³⁸, Renee Wilson³⁸, Sugi Mahes³⁸, John Seibyl²⁵, Christina Salerno²⁵, Christopher Coffey²⁷, Chelsea Caspell-Garcia²⁷, Arthur Toga³², Karen Crawford³², Tatiana Foroud³⁵, Paola Casalin³⁹, Giulia Malferrari³⁹, Mali Gani Weisz⁴⁰, Avi Orr-Urtreger⁴⁰, John Trojanowski²⁶, Leslie Shaw²⁶, Andrew Singleton³⁰, Tatiana Foroud³⁵, Tatiana Foroud³⁵, Thomas Montine³⁶, Tatiana Foroud³⁵, David Russell²⁵, Caroline Tanner²⁸, Tanya Simuni²⁹, Nabila Dahodwala²⁶, Brit Mollenhauer³¹, Douglas Galasko³³, Werner Poewe³⁴, Nir Giladi⁴⁰, Stewart Factor⁴¹, Penelope Hogarth⁴², David Standaert⁴³, Robert Hauser⁴⁴, Joseph Jankovic⁴⁵, Marie Saint-Hilaire⁴⁶, Irene Richard⁴⁷, David Shprecher⁴⁸, Hubert Fernandez⁴⁹, Katrina Brockmann⁵⁰, Liana Rosenthal⁵¹, Paolo Barone⁵², Alberto Espay⁵³, Dominic Rowe⁵⁴, Karen Marder⁵⁵, Anthony Santiago⁵⁶, Susan Bressman⁵⁷, Shu-Ching Hu⁵⁸, Stuart Isaacson⁵⁹, Jean-Christophe Corvol⁶⁰, Javiar Ruiz Martinez⁶¹, Eduardo Tolosa⁶², Yen Tai⁶³, Marios Politis⁶⁴, Debra Smejdir²⁵, Linda Rees²⁵, Karen Williams²⁷, Farah Kausar²⁸, Karen Williams²⁹, Whitney Richardson²⁶, Diana Willeke³¹, Shawnees Peacock³³, Beatrice Heim³⁴, Anat Mirelman⁴⁰, Barbara Sommerfeld⁴¹, Alison Freed⁴², Katrina Wakeman⁴², Courtney Blair⁴³, Stephanie Guthrie⁴⁵, Leigh Harrell⁴⁴, Christine Hunter⁴⁵, Cathi-Ann Thomas⁴⁶, Raymond James⁴⁶, Grace Zimmerman⁴⁷, Victoria Brown⁴⁸, Jennifer Mule⁴⁹, Ella Hilt⁵⁰, Kori Ribb⁵¹, Susan Ainscough⁵², Misty Wethington⁵³, Madelaine Ranola⁵⁴, Helen Mejia Santana⁵⁵, Juliana Moreno⁵⁶, Deborah Raymond⁵⁷, Krista Speketer⁵⁸, Lisbeth Carvajal⁵⁹, Stephanie Carvalho⁶⁰, Ioana Croitoru⁶¹, Alicia Garrido⁶², Laura Marie Payne⁶³, Veena Viswanth⁶⁵, Lawrence Severt⁶⁵, Maurizio Facheris⁶⁶, Holly Soares⁶⁶, Mark A Mintun⁶⁷, Jesse Cedarbaum⁶⁸, Peggy Taylor⁶⁹, Kevin Biglan⁷⁰, Emily Vandenbroucke⁷¹, Zulfiqar Haider Sheikh⁷¹, Baris Bingol⁷², Tanya Fischer⁷³, Pablo Sardi⁷³, Remi Forrat⁷³, Alastair Reith⁷⁴, Jan Egebjerg⁷⁵, Gabrielle Ahlberg Hillert⁷⁵, Barbara Saba⁷⁶, Chris Min⁷⁷, Robert Umek⁷⁸, Joe Mather⁷⁹, Susan De Santi⁸⁰, Anke Post⁸¹, Frank Boess⁸¹, Kirsten Taylor⁸¹, Igor Grachev⁸², Andreja Avbersek⁸³, Pierandrea Muglia⁸³, Kaplana Merchant⁸⁴, Johannes Tauscher⁸⁵

Affiliations

¹ Northwestern University Feinberg School of Medicine, USA. Electronic address: neha.prakash@northwestern.edu.
² The University of Iowa, USA. Electronic address: chelsea-caspell@uiowa.edu.
³ The University of Iowa, USA. Electronic address: christopher-coffey@uiowa.edu.
⁴ The University of Pennsylvania, USA. Electronic address: Andrew.siderowf@uphs.upenn.edu.
⁵ University of California San Francisco, USA. Electronic address: caroline.tanner@ucsf.edu.
⁶ University of Rochester Medical Center, USA. Electronic address: karl.kieburtz@chet.rochester.edu.
⁷ Center of Parkinsonism and Movement Disorders Paracelsus-Elena Klinik Kassel and University Medical Center Goettingen, Germany. Electronic address: brit.mollenhauer@med.uni-goettingen.de.
⁸ University of California San Diego, USA. Electronic address: dgalasko@ucsd.edu.
⁹ TransThera Consulting, USA. Electronic address: merchant.transthera@gmail.com.
¹⁰ Indiana University, USA. Electronic address: tforoud@iu.edu.
¹¹ University of Pittsburgh, USA. Electronic address: lanachahine@pitt.edu.
¹² The University of Pennsylvania, USA. Electronic address: daniel.weintraub@uphs.penn.edu.
¹³ University of Rochester Medical Center, USA. Electronic address: cindy.casaceli@chet.rochester.edu.
¹⁴ University of Rochester Medical Center, USA. Electronic address: ray.dorsey@chet.rochester.edu.
¹⁵ Clinical Trial Coordination Center, University of Rochester Medical Center, USA. Electronic address: renee.wilson@chet.rochester.edu.
¹⁶ Michael J Fox Foundation, USA.
¹⁷ Institute for Neurodegenerative Disorders, USA. Electronic address: ndaegele@invicro.com.
¹⁸ Michael J Fox Foundation, USA. Electronic address: varnedo@michaeljfox.org.
¹⁹ Michael J Fox Foundation, USA. Electronic address: mfrasier@michaeljfox.org.
²⁰ Michael J Fox Foundation, USA. Electronic address: tsherer@michaeljfox.org.
²¹ Institute for Neurodegenerative Disorders, USA. Electronic address: kmarek@mnimaging.com.
²² Harvard Medical School, Beth Israel Deaconess Medical Center, Parkinson's Disease and Movement Disorders Center, Director of the HDSA Center of Excellence, USA. Electronic address: sfrank2@bidmc.harvard.edu.
²³ Denali Therapeutics, USA. Electronic address: jennings@dnli.com.
²⁴ Northwestern University Feinberg School of Medicine, USA. Electronic address: tsimuni@nmff.org.
²⁵ Institute for Neurodegenerative Disorders, New Haven, CT, USA.
²⁶ University of Pennsylvania, Philadelphia, PA, USA.
²⁷ University of Iowa, Iowa City, IA, USA.
²⁸ University of California, San Francisco, CA, USA.
²⁹ Northwestern University, Chicago, IL, USA.
³⁰ National Institute on Aging, NIH, Bethesda, MD, USA.
³¹ Paracelsus-Elena Klinik, Kassel, Germany.
³² Laboratory of Neuroimaging (LONI), University of Southern California, Los Angeles, CA, USA.
³³ University of California, San Diego, CA, USA.
³⁴ Innsbruck Medical University, Innsbruck, Austria.
³⁵ Indiana University, Indianapolis, IN, USA.
³⁶ Stanford University, Stanford, CA, USA.
³⁷ The Michael J. Fox Foundation for Parkinson's Research, New York, NY, USA.
³⁸ Clinical Trials Coordination Center, University of Rochester, Rochester, NY, USA.
³⁹ BioRep, Milan, Italy.
⁴⁰ Tel Aviv Medical Center, Tel Aviv, Israel.
⁴¹ Emory University of Medicine, Atlanta, GA, USA.
⁴² Oregon Health and Science University, Portland, OR, USA.
⁴³ University of Alabama at Birmingham, Birmingham, AL, USA.
⁴⁴ University of South Florida, Tampa, FL, USA.
⁴⁵ Baylor College of Medicine, Houston, TX, USA.
⁴⁶ Boston University, Boston, MA, USA.
⁴⁷ University of Rochester, Rochester, NY, USA.
⁴⁸ Banner Research Institute, Sun City, AZ, USA.
⁴⁹ Cleveland Clinic, Cleveland, OH, USA.
⁵⁰ University of Tuebingen, Tuebingen, Germany.
⁵¹ Johns Hopkins University, Baltimore, MD, USA.
⁵² University of Salerno, Salerno, Italy.
⁵³ University of Cincinnati, Cincinnati, OH, USA.
⁵⁴ Macquarie University, Sydney, Australia.
⁵⁵ Columbia University, New York, NY, USA.
⁵⁶ The Parkinson's Institute, Sunnyvale, CA, USA.
⁵⁷ Beth Israel Medical Center, New York, NY, USA.
⁵⁸ University of Washington, Seattle, WA, USA.
⁵⁹ Parkinson's Disease and Movement Disorders Center of Boca Raton, Boca Raton, FL, USA.
⁶⁰ Hospital Pitie-Salpetriere, Paris, France.
⁶¹ Hospital Donostia, San Sebastian, Spain.
⁶² Hospital Clinic de Barcelona, Barcelona, Spain.
⁶³ Imperial College London, London, United Kingdom.
⁶⁴ King's College London, London, United Kingdom.
⁶⁵ Allergan, Dublin, Ireland.
⁶⁶ Abbvie, North Chicago, IL, USA.
⁶⁷ Avid Radiopharmaceuticals, Inc, Philadelphia, PA, USA.
⁶⁸ Biogen Idec, Cambridge, MA, USA.
⁶⁹ BioLegend, Dedham, MA, USA.
⁷⁰ Eli Lilly and Company, Indianapolis, IN, USA.
⁷¹ GE Healthcare, Princeton, NJ, USA.
⁷² Genentech, San Francisco, CA, USA.
⁷³ Genzyme Sanofi, Cambridge, MA, USA.
⁷⁴ GlaxoSmithKline, Brentford, United Kingdom.
⁷⁵ H. Lundbeck A/S, Copenhagen, Denmark.
⁷⁶ Institut de Recherches Internationales Servier, Neuilly-sur-Seine, France.
⁷⁷ Merck and Co., Kenilworth, NJ, USA.
⁷⁸ Meso Scale Diagnostics, Rockville, MD, USA.
⁷⁹ Pfizer Inc, Cambridge, MA, USA.
⁸⁰ Piramal Group, Mumbai, India.
⁸¹ F. Hoffmann-La Roche Limited, Basel, Switzerland.
⁸² Teva Pharmaceutical Industries, Petah Tikva, Israel.
⁸³ UCB Pharma, Brussel, Belgium.
⁸⁴ TransThera Consulting, Portland, OR, USA.
⁸⁵ Takeda, Osaka, Japan.

PMID: 30738748
PMCID: PMC8978879
DOI: 10.1016/j.parkreldis.2018.12.025

Abstract

Objective: To determine the feasibility, safety and tolerability of lumbar punctures (LPs) in research participants with early Parkinson disease (PD), subjects without evidence of dopaminergic deficiency (SWEDDs) and healthy volunteers (HC).

Background: Cerebrospinal fluid (CSF) analysis is becoming an essential part of the biomarkers discovery effort in PD with still limited data on safety and feasibility of serial LPs in PD participants.

Design/methods: Parkinson's Progression Marker Initiative (PPMI) is a longitudinal observation study designed to identify PD progression biomarkers. All PPMI participants undergo LP at baseline, 6, 12 months and yearly thereafter. CSF collection is performed by a trained investigator using predominantly atraumatic needles. Adverse events (AEs) are monitored by phone one week after LP completion. We analyzed safety data from baseline LPs.

Results: PPMI enrolled 683 participants (423 PD/196 HC/64 SWEDDs) from 23 study sites. CSF was collected at baseline in 97.5% of participants, of whom 5.4% underwent collection under fluoroscopy. 23% participants reported any related AEs, 68% of all AE were mild while 5.6% were severe. The most common AEs were headaches (13%) and low back pain (6.5%) and both occurred more commonly in HC and SWEDDs compared to PD participants. Factors associated with higher incidence of AEs across the cohorts included female gender, younger age and use of traumatic needles with larger diameter. AEs largely did not impact compliance with the future LPs.

Conclusions: LPs are safe and feasible in PD research participants. Specific LP techniques (needle type and gauge) may reduce the overall incidence of AEs.

Keywords: Adverse events; Lumbar puncture; Parkinson's disease; Safety.

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References

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Feasibility and safety of lumbar puncture in the Parkinson's disease research participants: Parkinson's Progression Marker Initiative (PPMI)

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Feasibility and safety of lumbar puncture in the Parkinson's disease research participants: Parkinson's Progression Marker Initiative (PPMI)

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