Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2019 Apr;7(4):347-349.
doi: 10.1016/j.jchf.2018.12.012. Epub 2019 Feb 6.

Reframing Global Variation in Heart Failure Trials: Thinking Beyond Location on the Map

Stephen J Greene  1 , Robert M Califf  2
Affiliations
Editorial

Reframing Global Variation in Heart Failure Trials: Thinking Beyond Location on the Map

Stephen J Greene et al. JACC Heart Fail. 2019 Apr.
No abstract available

Keywords: clinical trial; globalization; heart failure; income.

PubMed Disclaimer

Comment on

  • Income Inequality and Outcomes in Heart Failure: A Global Between-Country Analysis.
    Dewan P, Rørth R, Jhund PS, Ferreira JP, Zannad F, Shen L, Køber L, Abraham WT, Desai AS, Dickstein K, Packer M, Rouleau JL, Solomon SD, Swedberg K, Zile MR, McMurray JJV; PARADIGM-HF and ATMOSPHERE Investigators. Dewan P, et al. JACC Heart Fail. 2019 Apr;7(4):336-346. doi: 10.1016/j.jchf.2018.11.005. Epub 2019 Feb 6. JACC Heart Fail. 2019. PMID: 30738981 Clinical Trial.

References

    1. Glickman SW, McHutchison JG, Peterson ED, et al. Ethical and scientific implications of the globalization of clinical research. N Engl J Med 2009;360:816–23. - PubMed
    1. Ferreira JP, Girerd N, Rossignol P, Zannad F. Geographic differences in heart failure trials. Eur J Heart Fail 2015;17:893–905. - PubMed
    1. Greene SJ, Fonarow GC, Solomon SD, et al. Global variation in clinical profile, management, and post-discharge outcomes among patients hospitalized for worsening chronic heart failure: findings from the ASTRONAUT trial. Eur J Heart Fail 2015;17:591–600. - PubMed
    1. Pfeffer MA, Claggett B, Assmann SF, et al. Regional variation in patients and outcomes in the Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) Trial. Circulation 2014;131:34–42. - PubMed
    1. Packer M, O’Connor C, McMurray JJV, et al. Effect of ularitide on cardiovascular mortality in acute heart failure. N Engl J Med 2017;376: 1956–64. - PubMed