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Comment
. 2019 Jul;49(10):1624-1628.
doi: 10.1017/S003329171800421X. Epub 2019 Feb 11.

Meta-analytic studies of the glial cell marker TSPO in psychosis - a question of apples and pears?

P Plavén-Sigray  1 , S Cervenka  1
Affiliations
Comment

Meta-analytic studies of the glial cell marker TSPO in psychosis - a question of apples and pears?

P Plavén-Sigray et al. Psychol Med. 2019 Jul.

Erratum in

No abstract available

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Figures

Fig. 1.
Fig. 1.
The different outcomes used by the studies included in the (R)-[11C]PK11195 meta-analysis by Marques et al. show little to no association with one another. This figure presents pooled data from 12 (R)-[11C]PK11195 examinations of healthy controls from a set of different regions (whole gray matter, thalamus, frontal cortex, hippocampus and striatum).
Fig. 2.
Fig. 2.
The magnitude of the effect size and the measurement error of the studies included in the (R)-[11C]PK11195 meta-analysis by Marques et al. (left figure) show a high degree of association (r = 0.9). Potential reasons for such a shape are publication bias or inflated effect sizes in studies with unreliable outcomes and small sample sizes, leading to an inflated overall effect size. When Marques et al. corrected for this bias, the difference between healthy controls and patients with psychosis or schizophrenia was no longer statistically significant (right figure).
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