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. 2019 Jan 25:9:703.
doi: 10.3389/fgene.2018.00703. eCollection 2018.

Identification of Alzheimer's Disease-Related Genes Based on Data Integration Method

Yang Hu  1 , Tianyi Zhao  1 , Tianyi Zang  1 , Ying Zhang  2 , Liang Cheng  3
Affiliations

Identification of Alzheimer's Disease-Related Genes Based on Data Integration Method

Yang Hu et al. Front Genet. .

Abstract

Alzheimer disease (AD) is the fourth major cause of death in the elderly following cancer, heart disease and cerebrovascular disease. Finding candidate causal genes can help in the design of Gene targeted drugs and effectively reduce the risk of the disease. Complex diseases such as AD are usually caused by multiple genes. The Genome-wide association study (GWAS), has identified the potential genetic variants for most diseases. However, because of linkage disequilibrium (LD), it is difficult to identify the causative mutations that directly cause diseases. In this study, we combined expression quantitative trait locus (eQTL) studies with the GWAS, to comprehensively define the genes that cause Alzheimer disease. The method used was the Summary Mendelian randomization (SMR), which is a novel method to integrate summarized data. Two GWAS studies and five eQTL studies were referenced in this paper. We found several candidate SNPs that have a strong relationship with AD. Most of these SNPs overlap in different data sets, providing relatively strong reliability. We also explain the function of the novel AD-related genes we have discovered.

Keywords: Alzheimer disease; GWAS; SNPs; eQTL; mendelian randomization.

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Figures

Figure 1
Figure 1
Generalization of Mendel's randomized method.
Figure 2
Figure 2
Work flow of SMR.
Figure 3
Figure 3
The number of repetitions of SNPs.
Figure 4
Figure 4
Number of gene duplication.
Figure 5
Figure 5
The number of papers found in the ALZgene.
See this image and copyright information in PMC

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