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Review
. 2019 Feb 9;20(3):735.
doi: 10.3390/ijms20030735.

Long Non-Coding RNA and Acute Leukemia

Gabriela Marisol Cruz-Miranda  1 , Alfredo Hidalgo-Miranda  2 , Diego Alberto Bárcenas-López  3 , Juan Carlos Núñez-Enríquez  4 , Julian Ramírez-Bello  5 , Juan Manuel Mejía-Aranguré  6 , Silvia Jiménez-Morales  7
Affiliations
Review

Long Non-Coding RNA and Acute Leukemia

Gabriela Marisol Cruz-Miranda et al. Int J Mol Sci. .

Abstract

Acute leukemia (AL) is the main type of cancer in children worldwide. Mortality by this disease is high in developing countries and its etiology remains unanswered. Evidences showing the role of the long non-coding RNAs (lncRNAs) in the pathophysiology of hematological malignancies have increased drastically in the last decade. In addition to the contribution of these lncRNAs in leukemogenesis, recent studies have suggested that lncRNAs could be used as biomarkers in the diagnosis, prognosis, and therapeutic response in leukemia patients. The focus of this review is to describe the functional classification, biogenesis, and the role of lncRNAs in leukemogenesis, to summarize the evidence about the lncRNAs which are playing a role in AL, and how these genes could be useful as potential therapeutic targets.

Keywords: acute leukemia; cancer; long non-coding RNAs; therapeutic targets.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Positional classification of the long non-coding RNAs (lncRNA). Carton displays the LncRNA (red) classification base on (a) the location between two coding genes (intronic, exonic, intergenic, or overlapping), (b) the template strand (sense, antisense), and (c) transcription direction when coding genes and lncRNA are transcribed in the same strand (divergent, convergent). Gray arrow indicates in which direction transcription is proceed. Green and blue boxes represent exons of two different genes.
See this image and copyright information in PMC

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