Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jan-Mar;14(1):75-82.
doi: 10.4103/atm.ATM_145_18.

Immunization status in chronic obstructive pulmonary disease: A multicenter study from Turkey

Tevfik Ozlu  1 , Yilmaz Bulbul  1 , Derya Aydin  2 , Dursun Tatar  3 , Tulin Kuyucu  4 , Fatma Erboy  5 , Handan Inonu Koseoglu  6 , Ceyda Anar  3 , Aysel Sunnetcioglu  7 , Pinar Yildiz Gulhan  8 , Unal Sahin  9 , Aydanur Ekici  10 , Serap Duru  11 , Sevinc Sarinc Ulasli  12 , Ercan Kurtipek  13 , Sibel Gunay  14 ; RIMPACT Study Investigators
Affiliations

Immunization status in chronic obstructive pulmonary disease: A multicenter study from Turkey

Tevfik Ozlu et al. Ann Thorac Med. 2019 Jan-Mar.

Abstract

Objective: The purpose of this study is to detect the prevalence and the factors associated with influenza and pneumococcal vaccination and outcomes of vaccination during 2013-2014 season in patients with chronic obstructive pulmonary disease (COPD) in Turkey.

Methods: This was a multicenter retrospective cohort study performed in 53 different centers in Turkey.

Results: During the study period, 4968 patients were included. COPD was staged as GOLD 1-2-3-4 in 9.0%, 42.8%, 35.0%, and 13.2% of the patients, respectively. Influenza vaccination rate in the previous year was 37.9%; and pneumococcus vaccination rate, at least once during in a life time, was 13.3%. Patients with older age, higher level of education, more severe COPD, and comorbidities, ex-smokers, and patients residing in urban areas had higher rates of influenza vaccination. Multivariate logistic regression analysis showed that advanced age, higher education levels, presence of comorbidities, higher COPD stages, and exacerbation rates were associated with both influenza and pneumococcal vaccination. The number of annual physician/outpatient visits and hospitalizations due to COPD exacerbation was 2.73 ± 2.85 and 0.92 ± 1.58 per year, respectively. Patients with older age, lower education levels, more severe COPD, comorbid diseases, and lower body mass index and patients who are male and are residing in rural areas and vaccinated for influenza had significantly higher rates of COPD exacerbation.

Conclusions: The rates of influenza and pneumococcal vaccination in COPD patients were quite low, and the number of annual physician/outpatient visits and hospitalizations due to COPD exacerbation was high in Turkey. Advanced age, higher education levels, comorbidities, and higher COPD stages were associated with both influenza and pneumococcal vaccination.

Keywords: Chronic obstructive pulmonary disease; chronic obstructive pulmonary disease exacerbation; influenza vaccine; pneumococcal vaccine.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

References

    1. Mannino DM, Homa DM, Akinbami LJ, Ford ES, Redd SC. Chronic obstructive pulmonary disease surveillance – United states, 1971-2000. MMWR Surveill Summ. 2002;51:1–6. - PubMed
    1. Menezes AM, Perez-Padilla R, Jardim JR, Muiño A, Lopez MV, Valdivia G, et al. Chronic obstructive pulmonary disease in five Latin American cities (the PLATINO study): A prevalence study. Lancet. 2005;366:1875–81. - PubMed
    1. de Marco R, Accordini S, Cerveri I, Corsico A, Sunyer J, Neukirch F, et al. An international survey of chronic obstructive pulmonary disease in young adults according to GOLD stages. Thorax. 2004;59:120–5. - PMC - PubMed
    1. COPD group of the Hellenic Thoracic Society. Tzanakis N, Anagnostopoulou U, Filaditaki V, Christaki P, Siafakas N, et al. Prevalence of COPD in greece. Chest. 2004;125:892–900. - PubMed
    1. Peña VS, Miravitlles M, Gabriel R, Jiménez-Ruiz CA, Villasante C, Masa JF, et al. Geographic variations in prevalence and underdiagnosis of COPD: Results of the IBERPOC multicentre epidemiological study. Chest. 2000;118:981–9. - PubMed