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. 2019 Jan 27;7(2):253-255.
doi: 10.3889/oamjms.2019.065. eCollection 2019 Jan 30.

Successful Psoriasis Treatment Using NB-UVB with Methotrexate: The Vietnamese Experience

Em Dang Van  1 , Thuy Pham Diem  2 , Van Bui Thi  1 , Tam Huynh Thi Xuan  3 , Khai Ly Tuan  1 , Trang Nguyen Quynh  1 , Trang Vu Thu  1 , Thuong Nguyen Van  4 , Sau Nguyen Huu  4 , Phuong Pham Thi Minh  4 , Nghi Dinh Huu  4 , Tam Hoang Van  4 , Khang Tran Hau  4 , Marco Gandolfi  5 , Francesca Satolli  5 , Claudio Feliciani  5 , Michael Tirant  6   7 , Aleksandra Vojvodic  8 , Torello Lotti  6
Affiliations

Successful Psoriasis Treatment Using NB-UVB with Methotrexate: The Vietnamese Experience

Em Dang Van et al. Open Access Maced J Med Sci. .

Abstract

Aim: To compare the effectiveness of narrowband ultraviolet B (NBUVB) and oral methotrexate (MTX) to oral MTX alone in Vietnamese psoriasis patients, from May 2016 to May 2018.

Methods: We conducted a non-randomized trial on 70 patients with plaque-type psoriasis of moderate to severe. Thirty-five patients apply NBUVB once/day in 5 days/week for 4 weeks plus oral MTX 7.5 mg/week and 35 patients oral MTX 7.5 mg/week and both two groups treatment for 3 months. The extent of the lesion was assessed by the Psoriasis Area and Severity Index (PASI).

Results: The proportion of decreasing PASI was comparable (68.49% in NBUVB and MTX versus 57.62% in MTX alone); p < 0.05. Inside, good 28.58%, moderate 68.57% and poor 2.85% in NBUVB and MTX better than good 2.85%, moderate 71.4% and poor 25.72% in MTX alone; p < 0.05. The recurrence rate after 24 months of the NBUVB and MTX group (42.9%) was lower than the MTX alone group (71.4%); p < 0.05.

Conclusion: NBUVB and oral MTX have affected treatment with chronic plaque psoriasis better than oral MTX alone.

Keywords: Methotrexate; Narrowband ultraviolet B; Psoriasis vulgaris.

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