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. 2019 Jan 27;7(2):302-303.
doi: 10.3889/oamjms.2019.066. eCollection 2019 Jan 30.

Quality of Life in Psoriasis Vietnamese Patients Treated with Metformin in Combination with Methotrexate

Affiliations

Quality of Life in Psoriasis Vietnamese Patients Treated with Metformin in Combination with Methotrexate

Tam Huynh Thi Xuan et al. Open Access Maced J Med Sci. .

Abstract

A cross-sectional study was performed on 48 psoriasis Vietnamese patients treated with metformin as an add-on for methotrexate and 48 psoriasis patients treated methotrexate alone. The mean PASI scores were 5.25 ± 5.72. Total QOL scores had a slight difference between patients treated metformin combined with methotrexate and methotrexate alone (62.32 ± 18.1 vs 60.91 ± 19.63). Combined therapy with metformin and methotrexate contributes to significantly improve the quality of life for patients with psoriasis.

Keywords: Metformin; Methotrexate; Psoriasis.

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References

    1. Liang SE, Cohen JM, Ho RS. Psoriasis and suicidality:A review of the literature. Dermatologic therapy. 2018;12:e12771. https://doi.org/10.1111/dth.12771 PMid:30315629. - PubMed
    1. Darjani A, Heidarzadeh A, Golchai J, Sadr-Eshkevari S, Alizadeh N, Arami M, Nichhah N. Quality of life in psoriatic patients:a study using the short form-36. International journal of preventive medicine. 2014;5(9):1146. PMid:25317298 PMCid:PMC4192777. - PMC - PubMed
    1. Damevska K, França K, Lotti T, Nikolovska S, Pollozhani N. Complementary and integrative therapies for psoriasis:Looking forward. Dermatologic therapy. 2018;31(5):12627. https://doi.org/10.1111/dth.12627 PMid:30133906. - PubMed
    1. Glossmann H, Reider N. A marriage of two “Methusalem“drugs for the treatment of psoriasis?Arguments for a pilot trial with metformin as an add-on for methotrexate. Dermato-endocrinology. 2013;5(2):252–63. https://doi.org/10.4161/derm.23874 PMid:24194965 PMCid:PMC37729135. - PMC - PubMed
    1. Li W, Ma W, Zhong H, Liu W, Sun Q. Metformin inhibits proliferation of human keratinocytes through a mechanism associated with activation of the MAPK signalling pathway. Experimental and therapeutic medicine. 2014;7(2):389–92. https://doi.org/10.3892/etm.2013.1416 PMid:24396411 PMCid:PMC3881035. - PMC - PubMed

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