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Case Reports
. 2018 Nov 8;6(1):77-80.
doi: 10.1002/mdc3.12689. eCollection 2019 Jan.

Imaging Tau, Neuroinflammation, and Aβ in Dementia With Lewy Bodies: A Deep-Phenotyping Case Report

Elijah Mak  1 , Ajenthan Surendranathan  1 , Nicolas Nicastro  1 , Franklin Aigbirhio  2 , James Rowe  2   3   4 , John O'Brien  1
Affiliations
Case Reports

Imaging Tau, Neuroinflammation, and Aβ in Dementia With Lewy Bodies: A Deep-Phenotyping Case Report

Elijah Mak et al. Mov Disord Clin Pract. .
No abstract available

Keywords: PET; amyloid; dementia with Lewy bodies; neuroinflammation; tau.

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Figures

Figure 1
Figure 1
Multimodal imaging profile of the DLB case. Structural MRI revealed moderate hippocampal atrophy and on FLAIR minimal WML burden. [11C]‐PiB binding showed a stereotypical AD‐like pattern characterized by diffuse binding, particularly within the precuneus and frontal cortices. The topographic distribution of [18F]‐AV1451 binding was atypical of AD, characterized with selectively higher uptake in the occipital cortices, paralleling with the distribution observed on the [11C]‐PK11195 scan. The topography of [18F]‐AV1451 binding showed an atypical pattern of occipital dominance. [18F]‐AV1451 binding strongly overlapped with that of [11C]‐PK11195 (r = 0.6; P < 0.001). Moreover, this spatial relationship was independent of [11C]‐PiB binding. Abbreviations: FLAIR, fluid‐attenuated inversion recovery; PIB, [11C]‐Pittsburgh Compound B; AV, [18F]‐AV1451; PK, [11C]‐PK11995; WML, white matter lesion; AQCER, Addenbrooke's Cognitive Examination Revised.
Figure 2
Figure 2
Delineating the regional distributions and spatial relationships across [11C]‐PiB, [11C]‐PK11195, and [18F]‐AV1451 retention patterns. The topography of [18F]‐AV1451 binding showed an atypical pattern of occipital dominance. [18F]‐AV1451 binding strongly overlapped with that of [11C]‐PK11195 (r = 0.6; P < 0.001). Moreover, this spatial relationship was independent of [11C]‐PiB binding. Abbreviations: PIB, [11C]‐Pittsburgh Compound B; AV, [18F]‐AV1451; PK, [11C]‐PK11995.
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