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Review
. 2019 Apr;28(4):678-683.
doi: 10.1002/pro.3588.

What has de novo protein design taught us about protein folding and biophysics?

David Baker  1
Affiliations
Review

What has de novo protein design taught us about protein folding and biophysics?

David Baker. Protein Sci. 2019 Apr.

Abstract

Recent progress in de novo protein design has led to an explosion of new protein structures, functions and assemblies. In this essay, I consider how the successes and failures in this new area inform our understanding of the proteins in nature and, more generally, the predictive computational modeling of biological systems.

Keywords: computational modeling; protein design; protein folding.

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References

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