Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Mar 1;21(5):1453-1457.
doi: 10.1021/acs.orglett.9b00208. Epub 2019 Feb 12.

Genome Mining of Streptomyces atratus SCSIO ZH16: Discovery of Atratumycin and Identification of Its Biosynthetic Gene Cluster

Changli Sun  1 , Zhijie Yang  1   2 , Chunyan Zhang  1   2 , Zhiyong Liu  3 , Jianqiao He  1   2 , Qing Liu  1   4 , Tianyu Zhang  3   2 , Jianhua Ju  1   2 , Junying Ma  1
Affiliations

Genome Mining of Streptomyces atratus SCSIO ZH16: Discovery of Atratumycin and Identification of Its Biosynthetic Gene Cluster

Changli Sun et al. Org Lett. .

Abstract

Genome mining of the deep sea-derived Streptomyces atratus SCSIO ZH16 enabled the activation of a cyclodepsipeptide gene cluster and isolation of its cinnamic acid-bearing product, atratumycin (1). Atratumycin's structure was elucidated on the basis of extensive spectroscopic experiments, X-ray data, and Marfey's method; a plausible biosynthesis and tailoring modification of 1 are also proposed and investigated. Additionally, atratumycin is active against Mycobacteria tuberculosis H37Ra and H37Rv with MICs of 3.8 and 14.6 μM, respectively.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources