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Review
. 2019 Feb 12;21(2):13.
doi: 10.1007/s11906-019-0921-3.

Personalized Medicine and the Treatment of Hypertension

Sarah Melville  1   2 , James Brian Byrd  3
Affiliations
Review

Personalized Medicine and the Treatment of Hypertension

Sarah Melville et al. Curr Hypertens Rep. .

Abstract

Purpose of review: The purpose of this review is to discuss the implications of personalized medicine for the treatment of hypertension, including resistant hypertension.

Recent findings: We suggest a framework for the personalized treatment of hypertension based on the concept of a trade-off between simplicity and personalization. This framework is based on treatment strategies classified as low, medium, or high information burden personalization approaches. The extent to which a higher information burden is justified depends on the clinical scenario, particularly the ease with which the blood pressure can be controlled. A one-size-fits-many treatment strategy for hypertension is efficacious for most people; however, a more personalized approach could be useful in patients with subtypes of hypertension that do not respond as expected to treatment. Clinicians seeing patients with unusual hypertension phenotypes should be familiar with emerging trends in personalized treatment of hypertension.

Keywords: Blood pressure; Hypertension; Personalized medicine; Population health; Primary aldosteronism; Resistant hypertension.

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Figures

Figure
Figure
A) Low information burden personalized medicine approaches can be adequate for treatment efficacy (e.g. one-size-fits-many). In some cases, however, the low information burden approaches to treatment do not provide effective results, so B) reasonable higher information burden personalized medicine approaches should be considered.
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