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. 2019 Sep 27;69(8):1440-1442.
doi: 10.1093/cid/ciz122.

Clinical Spectrum of Primaquine-induced Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficiency: A 9-Year Hospitalization-based Study From the Brazilian Amazon

Jose Diego Brito-Sousa  1   2 , Thalie C Santos  2 , Sara Avalos  3 , Gustavo Fontecha  3 , Gisely C Melo  1   2 , Fernando Val  1   2 , André M Siqueira  4 , Graça C Alecrim  1 , Quique Bassat  5   6   7   8 , Marcus V G Lacerda  1   9 , Wuelton M Monteiro  1   2
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Clinical Spectrum of Primaquine-induced Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficiency: A 9-Year Hospitalization-based Study From the Brazilian Amazon

Jose Diego Brito-Sousa et al. Clin Infect Dis. .

Abstract

Despite glucose-6-phosphate dehydrogenase (G6PD) deficiency prevalence of 5% in the Amazon, primaquine is administered without G6PD screening. This is an important cause of hospitalization among Plasmodium vivax-infected individuals, leading to life-threatening anemia and acute renal failure across endemic areas. In Manaus, the frequency of primaquine-induced hemolysis was 85.2 cases per 100 000 primaquine users.

Keywords: G6PD deficiency; acute renal failure; elimination; primaquine; severe anemia.

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