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. 2019 Jul 2;69(2):357-365.
doi: 10.1093/cid/ciy985.

Birth Cohort Studies Assessing Norovirus Infection and Immunity in Young Children: A Review

Jennifer L Cannon  1 , Benjamin A Lopman  2   3 , Daniel C Payne  3 , Jan Vinjé  3
Affiliations

Birth Cohort Studies Assessing Norovirus Infection and Immunity in Young Children: A Review

Jennifer L Cannon et al. Clin Infect Dis. .

Erratum in

Abstract

Globally, noroviruses are among the foremost causes of acute diarrheal disease, yet there are many unanswered questions on norovirus immunity, particularly following natural infection in young children during the first 2 years of life when the disease burden is highest. We conducted a literature review on birth cohort studies assessing norovirus infections in children from birth to early childhood. Data on infection, immunity, and risk factors are summarized from 10 community-based birth cohort studies conducted in low- and middle-income countries. Up to 90% of children experienced atleast one norovirus infection and up to 70% experienced norovirus-associated diarrhea, most often affecting children 6 months of age and older. Data from these studies help to fill critical knowledge gaps for vaccine development, yet study design and methodological differences limit comparison between studies, particularly for immunity and risk factors for disease. Considerations for conducting future birth cohort studies on norovirus are discussed.

Keywords: birth cohort; diarrhea; immunity; norovirus; vaccine.

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References

    1. Ahmed SM,Hall AJ,Robinson AE, et al. Global prevalence of norovirus in cases of gastroenteritis: a systematic review and meta-analysis. Lancet Infect Dis 2014; 14:725–30. - PMC - PubMed
    1. Pires SM,Fischer-Walker CL,Lanata CF, et al. Aetiology-specific estimates of the global and regional incidence and mortality of diarrhoeal diseases commonly transmitted through food. PLoS One 2015; 10:e0142927. - PMC - PubMed
    1. GBD Diarrhoeal Diseases Collaborators. Estimates of global, regional, and national morbidity, mortality, and aetiologies of diarrhoeal diseases: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Infect Dis 2017; 17:909–48. - PMC - PubMed
    1. Koo HL,Neill FH,Estes MK, et al. Noroviruses: the most common pediatric viral enteric pathogen at a large university hospital after introduction of rotavirus vaccination. J Pediatric Infect Dis Soc 2013; 2:57–60. - PMC - PubMed
    1. Payne DC,Vinjé J,Szilagyi PG, et al. Norovirus and medically attended gastroenteritis in U.S. children. N Engl J Med 2013; 368:1121–30. - PMC - PubMed

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