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. 2019 Jan 1:2019:baz012.
doi: 10.1093/database/baz012.

ImmunoSPdb: an archive of immunosuppressive peptides

Salman Sadullah Usmani  1   2 , Piyush Agrawal  1   2 , Manika Sehgal  2 , Pradeep Kumar Patel  2 , Gajendra P S Raghava  1   2
Affiliations

ImmunoSPdb: an archive of immunosuppressive peptides

Salman Sadullah Usmani et al. Database (Oxford). .

Abstract

Immunosuppression proved as a captivating therapy in several autoimmune disorders, asthma as well as in organ transplantation. Immunosuppressive peptides are specific for reducing efficacy of immune system with wide range of therapeutic implementations. `ImmunoSPdb' is a comprehensive, manually curated database of around 500 experimentally verified immunosuppressive peptides compiled from 79 research article and 32 patents. The current version comprises of 553 entries providing extensive information including peptide name, sequence, chirality, chemical modification, origin, nature of peptide, its target as well as mechanism of action, amino acid frequency and composition, etc. Data analysis revealed that most of the immunosuppressive peptides are linear (91%), are shorter in length i.e. up to 20 amino acids (62%) and have L form of amino acids (81%). About 30% peptide are either chemically modified or have end terminal modification. Most of the peptides either are derived from proteins (41%) or naturally (27%) exist. Blockage of potassium ion channel (24%) is one a major target for immunosuppressive peptides. In addition, we have annotated tertiary structure by using PEPstrMOD and I-TASSER. Many user-friendly, web-based tools have been integrated to facilitate searching, browsing and analyzing the data. We have developed a user-friendly responsive website to assist a wide range of users.

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Figures

Figure 1
Figure 1
Architecture of ImmunoSPdb.
Figure 2
Figure 2
Schematic representation of distribution of peptide entries in ImmunoSPdb based on (A) linear/cyclic conformation, (B) chirality, (C) nature and (D) length of immunosuppressive peptides.
Figure 3
Figure 3
Distribution of peptide entries based on (A) N-terminal, (B) C-terminal, (C) chemical modification and (D) target of action of immunosuppressive peptides.
Figure 4
Figure 4
Representative structures of various immunosuppressive peptides: (A) margatoxin having helix and sheets, (B) cycloamanide B having cyclic structure, (C) peptide named as SEQ ID 30 exhibit helical, (D) Ac-1-9 having N-terminal acetylation and (E) H17 having C-terminal amidation stored in ImmunoSPdb.
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