In vivo immunosuppression by synthetic pyrethroid (cypermethrin) pesticide in mice and goats

Abstract

Cypermethrin toxicity was produced in mice by intra-peritoneal injection of the pesticide at 50 mg/kg body weight per day for 26 days, and in goats by drenching with cypermethrin at 41.6 mg/kg body weight per day for 30 days. The status of cell-mediated immunity (CMI) was assessed by the 2,4-dinitrofluorobenzene (DNFB) skin sensitivity test. The results indicated significant depression of CMI in the cypermethrin-treated mice and goats. In addition, the humoral immune reaction of the goats intoxicated with cypermethrin was estimated by enumeration of the plaque-forming B-lymphocytes. The rate of plaque formation in the lymphocyte suspension of cypermethrin-treated goats was significantly reduced and the diameter of the plaques was also significantly lower than in that of control animals. The results indicated that cypermethrin suppressed both CMI and the antibody-forming ability of lymphocytes. This immunosuppressive action of cypermethrin is being reported for the first time.