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. 2019 Apr:146:66-71.
doi: 10.1016/j.apradiso.2019.01.020. Epub 2019 Jan 29.

Assessment of the radiation absorbed dose produced by 177Lu-iPSMA, 225Ac-iPSMA and 223RaCl2 to prostate cancer cell nuclei in a bone microenvironment model

Erika Azorín-Vega  1 , Eva Rojas-Calderón  2 , Guillermina Ferro-Flores  3 , Liliana Aranda-Lara  4 , Nallely Jiménez-Mancilla  5 , Miguel A Nava-Cabrera  6
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Assessment of the radiation absorbed dose produced by 177Lu-iPSMA, 225Ac-iPSMA and 223RaCl2 to prostate cancer cell nuclei in a bone microenvironment model

Erika Azorín-Vega et al. Appl Radiat Isot. 2019 Apr.

Abstract

This research aimed to assess the radiation absorbed dose produced by 177Lu-iPSMA (177Lu-prostate specific membrane antigen inhibitor), 225Ac-iPSMA and 223RaCl2 to prostate cancer cell nuclei in a simplified model of bone by using an experimental in-vitro prostate cancer LNCaP cell biokinetic study and Monte Carlo simulation with the MCNPX code. Results showed that 225Ac-iPSMA releases a nine hundred-fold radiation dose greater than 177Lu-iPSMA and 14 times more than 223RaCl2 per unit of activity retained in bone. 225Ac-iPSMA could be the best option for treatment of bone metastases in prostate cancer.

Keywords: Actinium-225; Lutetium-177; PSMA inhibitors; Prostate cancer; Theranostic radiopharmaceuticals.

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