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. 1978 Jun;20(3):714-20.
doi: 10.1128/iai.20.3.714-720.1978.

Trypanosoma rhodesiense infection in congenitally athymic (nude) mice

G H Campbell, K M Esser, S M Phillips

Trypanosoma rhodesiense infection in congenitally athymic (nude) mice

G H Campbell et al. Infect Immun. 1978 Jun.

Abstract

Athymic nude mice (nu/nu), heterozygous litter mates (nu/+), and thymic reconstituted homozygous animals (nu/nu TxR) were infected with Trypanosoma rhodesiense. A reduced parasitemia and prolonged survival were observed in the nu/nu animals after infection and cure or after immunization with irradiated organisms. These studies indicate that resistance of mice to T. rhodesiense infection is relatively independent of thymic lymphocyte function.

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