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. 2020 Feb;22(2):193-200.
doi: 10.1080/10286020.2018.1543280. Epub 2019 Feb 13.

Dendrodoristerol, a cytotoxic C20 steroid from the Vietnamese nudibranch mollusk Dendrodoris fumata

Pham Thi Mai Huong  1   2 , Nguyen Viet Phong  1 , Nguyen Phuong Thao  1 , Pham Thanh Binh  1 , Do Thi Thao  2   3 , Nguyen Van Thanh  1   2 , Nguyen Xuan Cuong  1 , Nguyen Hoai Nam  1 , Do Cong Thung  4 , Chau Van Minh  1
Affiliations

Dendrodoristerol, a cytotoxic C20 steroid from the Vietnamese nudibranch mollusk Dendrodoris fumata

Pham Thi Mai Huong et al. J Asian Nat Prod Res. 2020 Feb.

Abstract

Using various chromatographic separations, four steroids including one new C20 steroid namely dendrodoristerol (1), were isolated from the Vietnamese nudibranch mollusk Dendrodoris fumata. The structure elucidation was confirmed by combination of spectroscopic experiments including 1D and 2D NMR, HR QTOF MS, and CD. Compound 1 was found to exhibit significant in vitro cytotoxic activity against six human cancer cell lines as HL-60, KB, LU-1, MCF-7, LNCaP, and HepG2. In addition, 1 induced HL-60 cancer cell death by apoptosis and necrosis.

Keywords: Dendrodoris fumata; apoptosis; cytotoxicity; necrosis; steroid.

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