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Review
. 2019 Jan 29:8:F1000 Faculty Rev-116.
doi: 10.12688/f1000research.17109.1. eCollection 2019.

Recent advances in the clinical management of autosomal dominant polycystic kidney disease

Roser Torra  1
Affiliations
Review

Recent advances in the clinical management of autosomal dominant polycystic kidney disease

Roser Torra. F1000Res. .

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is a genetic systemic disorder causing the development of renal and hepatic cysts and decline in renal function. It affects around 1 in 1,000 live births. Early hypertension and progressive renal failure due to massive enlargement of cysts and fibrosis are hallmarks of the disease. This article reviews recent advances in ADPKD and focuses mainly on diagnosis, management, and prediction of the course of the disease.

Keywords: ADPKD; diagnosis; management; prediction; treatment.

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Conflict of interest statement

Competing interests: The author has received speaking fees and travel funding from Otsuka pharmaceutical. The author was member of the IDMC of the TEMPO trial.No competing interests were disclosed.No competing interests were disclosed.

Figures

Figure 1.
Figure 1.. Diagnosis and management of autosomal dominant polycystic kidney disease.
ACE/ARB, angiotensin-converting enzyme/angiotensin receptor blocker; ADPKD, autosomal dominant polycystic kidney disease; BMI, body mass index; eGFR, estimated glomerular filtration rate; ERA-EDTA, European Renal Association-European Dialysis and Transplant Association; hTKV, height-adapted total kidney volume; HTN, hypertension; LDL, low-density lipoprotein; PROPKD, Predicting Renal Outcome in Polycystic Kidney Disease; Uosm, urine osmolality. Modified from Chebib et al. and Chebib et al. .
See this image and copyright information in PMC

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    2. F1000 Recommendation

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