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Comparative Study
. 2019 Feb 7;32(1):e1422.
doi: 10.1590/0102-672020180001e1422.

ALVEOLAR BONE PATTERN AND SALIVARY LEPTIN LEVELS AMONG PREMENOPAUSAL OBESE WOMEN

[Article in English, Portuguese]
Silvia Helena de Carvalho Sales-Peres  1 , Francisco Carlos Groppo  2 , Rafaela Carolina Soares Bonato  1 , Matheus de Carvalho Sales-Peres  3 , Francisco Haiter-Neto  4 , Elinton Adami Chaim  5
Affiliations
Comparative Study

ALVEOLAR BONE PATTERN AND SALIVARY LEPTIN LEVELS AMONG PREMENOPAUSAL OBESE WOMEN

[Article in English, Portuguese]
Silvia Helena de Carvalho Sales-Peres et al. Arq Bras Cir Dig. .

Abstract
in English, Portuguese

Background: Systemic bone loss may lead to more severe periodontal destruction, decreasing local bone mineral density.

Aim: A cross-sectional designed was performed to study associations among alveolar bone pattern, salivary leptin concentrations, and clinical periodontal status in premenopausal obese and eutrophic women.

Methods: Thirty morbid obese (G1) and 30 normal-weight (G2) women were included. Anthropometric and periodontal measurements (probing depth - PD, clinical attachment levels - CAL, presence of calculus, bleeding on probing -BOP, and plaque accumulation) were assessed. OHIP-14 was used for assessment of oral health impact on quality of life. Panoramic radiography was used to obtain the panoramic mandibular index (PMI), mandibular cortical index (MCI), and mental index (MI). Intraoral periapical (PA) radiography was taken to measure the total trabecular bone volume. Leptin was measured in saliva of fasted overnight women.

Results: Groups 1 and 2 differed in all anthropometric aspects, but height. Pocket depth, calculus, BOP, and plaque index were worse in G1. No differences between groups were found considering OHIP. Normal-weight subjects showed higher proportion of dense bone trabeculae than obese subjects for pre-molars, but not for molars. Mental and panoramic mandibular indexes did not differ and were in normal level. Leptin concentration was dependent only on BMI.

Conclusion: Obesity affected the periodontal conditions, the alveolar bone pattern, and the salivary leptin concentration.

Racional:: A perda óssea sistêmica pode levar à destruição periodontal mais severa, diminuindo a densidade mineral óssea local.

Objetivo:: Investigar as associações entre padrão ósseo alveolar, concentrações de leptina salivar e estado periodontal em mulheres obesas na pré-menopausa e eutróficas.

Métodos:: Foram avaliadas 30 mulheres com obesidade mórbida (G1) e 30 com peso normal (G2). Foram analisadas as medidas antropométricas e periodontais (profundidade de sondagem - PS, nível clínico de inserção - NCI, presença de cálculo, sangramento à sondagem - SS e acúmulo de placa). O impacto da saúde bucal na qualidade de vida foi mensurado por meio do questionário OHIP-14. Radiografia panorâmica foi utilizada para obter o índice mandibular panorâmico (PMI), índice cortical mandibular (MCI) e índice mental (MI); já a radiografia periapical intraoral (AF) para medir o volume ósseo trabecular total. A leptina salivar foi coletada no período da manhã com a paciente em jejum.

Resultados:: Os grupos 1 e 2 diferiram em todos os aspectos antropométricos, exceto em estatura. Profundidade de bolsa, cálculo, SS e índice de placa foram piores no G1. Não foram encontradas diferenças entre os grupos considerando o OHIP. Indivíduos com peso normal apresentaram maior proporção de trabéculas ósseas densas do que os obesos para pré-molares, mas não para molares. Índices radiomorfométricos não diferiram entre os grupos e estavam dentro de valores normais. A concentração de leptina esteve associada ao IMC.

Conclusão:: A obesidade afetou as condições periodontais, o padrão ósseo alveolar e a concentração de leptina salivar.

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Conflict of interest statement

Conflict of interest: none

Figures

FIGURE 1
FIGURE 1. A) Median (bars) and interquartile deviation (whiskers) of CEJ-BL according to the groups and teeth aspects; B) median (bars) and interquartile deviation (whiskers) of CEJ-AP according to the groups and teeth aspects; C) median (bars) and interquartile deviation (whiskers) of alveolar bone loss according to the groups and teeth aspects; D) mental A and panoramic mandibular B indexes according to the groups and sides. Central line=median; boxes (1st and 2nd quartiles); whiskers=min and max values; E) salivary concentration (mean±SEM) of leptin according to the groups.
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