Cell-based Therapy for Chronic Obstructive Pulmonary Disease. Rebuilding the Lung

Abstract

As the prevalence and impact of lung diseases continue to increase worldwide, new therapeutic strategies are desperately needed. Advances in lung-regenerative medicine, a broad field encompassing stem cells, cell-based therapies, and a range of bioengineering approaches, offer new insights into and new techniques for studying lung physiology and pathophysiology. This provides a platform for the development of novel therapeutic approaches. Applicability to chronic obstructive pulmonary disease of recent advances and applications in cell-based therapies, predominantly those with mesenchymal stromal cell-based approaches, and bioengineering approaches for lung diseases are reviewed.

Keywords: bioengineering; cell therapy; mesenchymal stromal cell.

Figure 1.

Schematic demonstrating considerations for utilizing decellularized lung scaffolds. ECM = extracellular matrix; ESC = embryonic stem cell; iPS = induced pluripotent stem (cell). Reprinted by permission from Reference .