Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Feb 13:25:1187-1193.
doi: 10.12659/MSM.913387.

Comparison of Remifentanil-Based Fast-Track and Fentanyl-Based Routine Cardiac Anesthesia for Intraoperative Device Closure of Atrial Septal Defect (ASD) in Pediatric Patients

Qing Huang  1 , Lan-Ying Lin  1 , Xian-Zhong Lin  1
Affiliations

Comparison of Remifentanil-Based Fast-Track and Fentanyl-Based Routine Cardiac Anesthesia for Intraoperative Device Closure of Atrial Septal Defect (ASD) in Pediatric Patients

Qing Huang et al. Med Sci Monit. .

Abstract

BACKGROUND The aim of this study was to evaluate the effectiveness and safety of remifentanil-based fast-track anesthesia for intraoperative device closure of atrial septal defects (ASDs). MATERIAL AND METHODS The clinical data of 152 pediatric patients who received intraoperative device closure of ASD in our hospital from January 2015 to December 2017 were retrospectively analyzed. Patients were divided into 2 groups: group F (remifentanil-based fast-track anesthesia group, n=72) and group C (fentanyl-based routine anesthesia group, n=80). The relevant data from 2 groups were collected and analyzed. RESULTS No significant differences were found in the preoperative data or intraoperative hemodynamic index between these 2 groups. Group C was significantly inferior to group F regarding the duration of mechanical ventilation, length of intensive care unit (ICU) stay, length of hospital stay, and hospitalization expenses (P<0.05). In terms of postoperative complications, no death, third-degree atrioventricular block, occluder detachment, or residual leakage was reported in either group. The incidence of lung infections and bronchospasm was significantly higher in group C than in group F. There were no anesthetic-related complications. CONCLUSIONS The application of remifentanil-based fast-track anesthesia for intraoperative device closure of ASD is as effective and safe as fentanyl-based routine anesthesia. Moreover, remifentanil-based fast-track anesthesia has the advantages of shorter duration of mechanical ventilation, shorter length of hospital and ICU stay, fewer postoperative complications, and lower hospitalization expenses, and is therefore worthy of promotion in clinical practice.

PubMed Disclaimer

Conflict of interest statement

Conflict of interests

None.

References

    1. Kharouf R, Luxenberg DM, Khalid O, Abdulla R. Atrial septal defect: Spectrum of care. Pediatr Cardiol. 2008;29(2):271–80. - PubMed
    1. Luo H, Wang J, Qiao C, et al. Evaluation of different minimally invasive techniques in the surgical treatment of atrial septal defect. J Thorac Cardiovasc Surg. 2014;148(1):188–93. - PubMed
    1. Hoashi T, Yazaki S, Kagisaki K, et al. Management of ostium secundum atrial septal defect in the era of percutaneous trans-catheter device closure: 7-year experience at a single institution. J Cardiol. 2015;65(5):418–22. - PubMed
    1. Aytemir K, Oto A, Özkutlu S, et al. Transcatheter interatrial septal defect closure in a large cohort: Midterm follow-up results. Congenit Heart Dis. 2013;8(5):418–27. - PubMed
    1. Hongxin L, Wenbin G, Lanmin G, et al. Intraoperative device closure of atrial septal defect using a right minithoracotomy without cardiopulmonary bypass: Clinical analysis in 50 cases. Chin J Surg. 2005;43:653–54.