Functional role of specific secreted and cell surface molecules in tumour cell invasion and metastasis

Abstract

The invasion and metastatic spread of tumour cells are complex biological processes involving an array of cell surface and secreted protein molecules which function as specific recognition and catalytic agents in each step of the malignant cascade. In order to begin to identify these molecules and implicate them as true functioning agents, our laboratory has developed selected panels of monoclonal antibodies that have been screened for their ability to inhibit specific manifestations of the malignant phenotype in various model systems. Since monoclonal antibodies recognize only single and unique determinants, it is hypothesized that any monoclonal antibody which is specifically antifunctional will allow for the identification and isolation of relevant protein molecules.