Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Apr;18(4):327-341.
doi: 10.1080/14760584.2019.1582337. Epub 2019 Mar 20.

Impact of pneumococcal conjugate vaccines on hospitalizations for pneumonia in the United States

Andrew D Wiese  1 , Marie R Griffin  1   2   3 , Carlos G Grijalva  1   3
Affiliations
Review

Impact of pneumococcal conjugate vaccines on hospitalizations for pneumonia in the United States

Andrew D Wiese et al. Expert Rev Vaccines. 2019 Apr.

Abstract

Pneumonia is one of the leading causes of morbidity and mortality among children and older adults. Pneumococcal conjugate vaccines (PCVs) were introduced into the US routine infant vaccination schedule leading to substantial reductions of invasive pneumococcal diseases (IPD). PCV introduction also led to reductions in all-cause pneumonia among US children, though the indirect impact of PCVs on pneumonia in adults is difficult to quantify, especially due to the recent US recommendation for direct PCV use in older adults. Areas covered: We described the existing evidence for both the direct and indirect impact of PCVs on pneumonia among children and adults in the US since PCV introduction. Expert commentary: The introduction of PCVs into the US routine infant vaccination schedule led to important reductions in the burden of IPD and non-invasive pneumonia among vaccinated and unvaccinated populations. The impact of direct vaccination of older adults in the US since 2014, though difficult to quantify, is currently being evaluated. As pneumonia remains one of the leading causes of morbidity and mortality in the US, future evaluations of the direct and indirect effects of current and expanded valency PCVs in the US population are needed.

Keywords: Pneumococcal conjugate vaccines; pneumococcal disease; pneumonia; routine infant vaccination.

PubMed Disclaimer

Conflict of interest statement

Disclosures

ADW and MRG have no financial disclosures or conflicts of interest to report. CGG has received consulting fees from Pfizer, Sanofi and Merck and received research support from Sanofi-Pasteur, Campbell Alliance, the Centers for Disease Control and Prevention, National Institutes of Health, The Food and Drug Administration, and the Agency for Healthcare Research and Quality. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

References

    1. File TM. Community-acquired pneumonia. Lancet, 362(9400), 1991–2001 (2003). - PMC - PubMed
    1. File TM Jr., Tan JS. Pneumonia in older adults: reversing the trend. Jama, 294(21), 2760–2763 (2005). - PubMed
    1. Jackson ML, Neuzil KM, Thompson WW et al. The burden of community-acquired pneumonia in seniors: results of a population-based study. Clin Infect Dis, 39(11), 1642–1650 (2004). - PMC - PubMed
    1. Jain S, Self WH, Wunderink RG et al. Community-Acquired Pneumonia Requiring Hospitalization among U.S. Adults. N Engl J Med, 373(5), 415–427 (2015). - PMC - PubMed
    1. Rudan I, Boschi-Pinto C, Biloglav Z, Mulholland K, Campbell H. Epidemiology and etiology of childhood pneumonia. Bulletin of the World Health Organization, 86(5), 408–416 (2008). - PMC - PubMed

Publication types

MeSH terms