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Review
. 2019 Feb 12;11(2):150.
doi: 10.3390/v11020150.

Genetic Determinants of the Re-Emergence of Arboviral Diseases

Harshada Ketkar  1 , Daniella Herman  2 , Penghua Wang  3
Affiliations
Review

Genetic Determinants of the Re-Emergence of Arboviral Diseases

Harshada Ketkar et al. Viruses. .

Abstract

Mosquito-borne diseases constitute a large portion of infectious diseases, causing more than 700,000 deaths annually. Mosquito-transmitted viruses, such as yellow fever, dengue, West Nile, chikungunya, and Zika viruses, have re-emerged recently and remain a public health threat worldwide. Global climate change, rapid urbanization, burgeoning international travel, expansion of mosquito populations, vector competence, and host and viral genetics may all together contribute to the re-emergence of arboviruses. In this brief review, we summarize the host and viral genetic determinants that may enhance infectivity in the host, viral fitness in mosquitoes and viral transmission by mosquitoes.

Keywords: Arbovirus; evolution; genetic; host; re-emergence; vector.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Factors contributing to the re-emergence of arboviruses.
See this image and copyright information in PMC

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