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. 2018:4:39.
doi: 10.20517/2394-5079.2018.29. Epub 2018 Aug 1.

Oxidative stress and hepatocarcinogenesis

Ying Fu  1 , Fung-Lung Chung  2
Affiliations

Oxidative stress and hepatocarcinogenesis

Ying Fu et al. Hepatoma Res. 2018.

Abstract

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. There are two major challenges for HCC, the first being that early detection is generally not applicable, and secondly, it is usually fatal within several months after diagnosis. HCC is an inflammation-induced cancer. It is known that chronic inflammation leads to oxidative/nitrosative stress and lipid peroxidation, generating excess oxidative stress, together with aldehydes which can react with DNA bases to form promutagenic DNA adducts. In this review, the evidence between oxidative stress and liver carcinogenesis is summarized. We focused on the potential of using DNA adducts as oxidative stress biomarkers for liver carcinogenesis.

Keywords: DNA adduct; Oxidative stress; hepatocarcinogenesis; hepatocellular carcinoma; prevention.

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Conflict of interest statement

Conflicts of interest The authors declare that there are no conflicts of interest.

Figures

Figure 1.
Figure 1.
Oxidative stress and liver recurrence after surgery. HCC: hepatocellular carcinoma
See this image and copyright information in PMC

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