Constipation-induced pressor effects as triggers for cardiovascular events
- PMID: 30761728
- PMCID: PMC8030287
- DOI: 10.1111/jch.13489
Constipation-induced pressor effects as triggers for cardiovascular events
Abstract
Constipation is associated with cardiovascular events. Changes to the intestinal microbiota by constipation can induce atherosclerosis, blood pressure rise, and cardiovascular events. Constipation increases with age and often coexists with cardiovascular risk factors. In addition, strain at stool causes blood pressure rise, which can trigger cardiovascular events such as congestive heart failure, arrhythmia, acute coronary disease, and aortic dissection. However, because cardiovascular medical research often focuses on more dramatic interventions, the risk from constipation can be overlooked. Physicians caring for patients with cardiovascular disease should acknowledge constipation and straining with it as important cardiovascular risk, and prematurely intervene to prevent it. The authors review and discuss the relationship between constipation and cardiovascular disease.
Keywords: cardiovascular disease; constipation; hemodynamic atherothrombotic syndrome; intestinal microbiota; strain at stool; synergistic resonance hypothesis of blood pressure variability.
©2019 Wiley Periodicals, Inc.
Conflict of interest statement
None.
Figures
References
-
- Honkura K, Tomata Y, Sugiyama K, et al. Defecation frequency and cardiovascular disease mortality in Japan: The Ohsaki cohort study. Atherosclerosis. 2016;246:251‐256. - PubMed
-
- Fujii H, Yorozu T, Harada H, et al. Junkankishikkan to benpi [Cardiovascular Disease and Constipation]. Pharm Med. 1994;12:205‐211 (in Japanese).
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical