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Review
. 2019 Feb;15(2):81-90.
doi: 10.1200/JOP.18.00483.

Oral Anticancer Therapy: Management of Drug Interactions

Britny G Rogala  1 , Margaret M Charpentier  1 , Michelle K Nguyen  2 , Kaitlin M Landolf  3 , Lamya Hamad  4 , Kelly M Gaertner  5
Affiliations
Review

Oral Anticancer Therapy: Management of Drug Interactions

Britny G Rogala et al. J Oncol Pract. 2019 Feb.

Abstract

Oral anticancer therapy is increasingly integrated into the care of patients with cancer. Recognition and management of drug-drug interactions (DDIs) is critical to providing efficacious and safe anticancer treatment. DDIs with QTc-prolonging agents, anticoagulants, enzyme inducers and inhibitors, antidepressants, and acid suppressants are commonly encountered with anticancer therapies. Here, we review frequently observed DDIs and outline literature-supported suggestions for their management.

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