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Review
. 2019 Jul 26;30(6):573-580.
doi: 10.1515/revneuro-2018-0084.

Neurogenesis and brain aging

Nickolay K Isaev  1   2 , Elena V Stelmashook  2 , Elisaveta E Genrikhs  2
Affiliations
Free article
Review

Neurogenesis and brain aging

Nickolay K Isaev et al. Rev Neurosci. .
Free article

Abstract

Human aging affects the entire organism, but aging of the brain must undoubtedly be different from that of all other organs, as neurons are highly differentiated postmitotic cells, for the majority of which the lifespan in the postnatal period is equal to the lifespan of the entire organism. In this work, we examine the distinctive features of brain aging and neurogenesis during normal aging, pathological aging (Alzheimer's disease), and accelerated aging (Hutchinson-Gilford progeria syndrome and Werner syndrome).

Keywords: Alzheimer’s disease; Hutchinson-Gilford progeria syndrome; aging; brain; stem cells.

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