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Comment
. 2019 Feb 13;25(2):175-176.
doi: 10.1016/j.chom.2019.01.012.

Sugar and Fatty Acids Ack-celerate Prophage Induction

Anushila Chatterjee  1 , Breck A Duerkop  2
Affiliations
Comment

Sugar and Fatty Acids Ack-celerate Prophage Induction

Anushila Chatterjee et al. Cell Host Microbe. .

Abstract

Intestinal cues driving prophage induction in the microbiota are largely unknown. In this issue of Cell Host & Microbe, Oh et al. (2018) reveal that dietary fructose- and microbiota-derived short-chain fatty acids promote AckA-mediated acetic acid biosynthesis, triggering a stress response that facilities phage production.

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Figures

Figure 1.
Figure 1.. Fructose and SCFAs drive prophage induction in L. reuteri 6475.
The L. reuteri 6475 genome harbors two prophages LRɸ1 (blue) and LRɸ2 (yellow). Dietary fructose and short-chain fatty acids (SCFAs) promote conversion of acetyl phosphate to acetic acid which is catalyzed by acetate kinase A (AckA). Accumulation of acetate causes DNA damage summoning RecA (green circles) to the DNA lesion. As a consequence, RecA facilitates prophage induction. Fructose exposure primarily induces LRɸ1 (blue), whereas SCFAs trigger excision of both prophages (blue and yellow).
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