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Comment
. 2019 Feb 13;25(2):177-179.
doi: 10.1016/j.chom.2019.01.020.

The Innate Sense of Bacteriophages

Paul L Bollyky  1 , Patrick R Secor  2
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Free article
Comment

The Innate Sense of Bacteriophages

Paul L Bollyky et al. Cell Host Microbe. .
Free article

Abstract

Perturbation of the gut microbiota is associated with inflammatory bowel disease, obesity, and even cancer. In this issue of Cell Host & Microbe, Gogokhia et al. 2019 sought to kill cancer-causing bacteria with bacteriophages. However, the bacteriophages themselves directly stimulated an immune response, which worsened inflammatory bowel disease pathogenesis.

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  • Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis.
    Gogokhia L, Buhrke K, Bell R, Hoffman B, Brown DG, Hanke-Gogokhia C, Ajami NJ, Wong MC, Ghazaryan A, Valentine JF, Porter N, Martens E, O'Connell R, Jacob V, Scherl E, Crawford C, Stephens WZ, Casjens SR, Longman RS, Round JL. Gogokhia L, et al. Cell Host Microbe. 2019 Feb 13;25(2):285-299.e8. doi: 10.1016/j.chom.2019.01.008. Cell Host Microbe. 2019. PMID: 30763538 Free PMC article.

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