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. 2019 Feb 11;49(1):147-152.
doi: 10.3906/sag-1805-220.

Comparison of reference systems in the assessment of age-related serum immunoglobulin levels in pediatric patients

İlknur Külhaş Çelik, Ersoy Civelek, Ayşe Metin, Tayfur Giniş, Müge Toyran, Emine Dibek Mısırlıoğlu, Can Naci Kocabaş

Comparison of reference systems in the assessment of age-related serum immunoglobulin levels in pediatric patients

İlknur Külhaş Çelik et al. Turk J Med Sci. .

Abstract

Background/aim: Ig level assessment is frequently used in the diagnosis and follow-up of immunodeficiency, as well as in studies investigating the prevalence of low serum Ig level in specific diseases.

Materials and methods: Patients who underwent Ig testing in the inpatient and outpatient clinics of our hospital in the years 2010–2016 were included. The Ig levels of the patients were assessed separately according to two reference systems commonly used in Turkey and another reference system used in the USA.

Results: A total of 20,138 patients (57.6% male) were included in the study. The median age of the patients was 55.7 months (interquartile range: 23.1–96.7). According to the reference intervals determined by Tezcan et al., 30.6% of the patients were deficient in one or more Ig values. This rate was 4 times higher than those based on the reference intervals determined by Aksu et al. (7.7%) and those in the Nelson Textbook of Pediatrics (6.8%). We also determined that the frequency of low Ig levels with three reference systems

Conclusion: In this study, we found that the rates of low Ig level in a group of pediatric patients differed significantly when evaluated using three different reference systems for age-related serum Ig levels

Keywords: Children; reference system; serum immunoglobulin levels.

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Conflict of interest statement

CONFLICT OF INTEREST:

none declared

Figures

Figure 1
Figure 1
The rates of low Ig levels with the three reference systems.
Figure 2
Figure 2
The frequency of low IgA levels with the three reference systems according to age.
Figure 3
Figure 3
The frequency of low IgG levels with the three reference systems according to age.
Figure 4
Figure 4
The frequency of low IgM levels with the three reference systems according to age.
See this image and copyright information in PMC

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