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Comment
. 2019 Apr;9(4):458.
doi: 10.1158/2159-8290.CD-NB2019-019. Epub 2019 Feb 14.

Lung Microbiota Promote Lung Cancer

No authors listed
Comment

Lung Microbiota Promote Lung Cancer

No authors listed. Cancer Discov. 2019 Apr.

Abstract

In mice predisposed to lung cancer, dysregulation of the lung's bacteria creates a proinflammatory environment that promotes tumor growth. Treating the animals with antibiotics or keeping them in bacteria-free conditions results in fewer and smaller tumors, implicating the local microbiota in the development of lung cancer.

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  • Commensal Microbiota Promote Lung Cancer Development via γδ T Cells.
    Jin C, Lagoudas GK, Zhao C, Bullman S, Bhutkar A, Hu B, Ameh S, Sandel D, Liang XS, Mazzilli S, Whary MT, Meyerson M, Germain R, Blainey PC, Fox JG, Jacks T. Jin C, et al. Cell. 2019 Feb 21;176(5):998-1013.e16. doi: 10.1016/j.cell.2018.12.040. Epub 2019 Jan 31. Cell. 2019. PMID: 30712876 Free PMC article.

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