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Comment
. 2019 Feb 14;133(7):631-632.
doi: 10.1182/blood-2018-12-891515.

Hepatocyte tPA: where have you been hiding?

Steven L Gonias  1
Affiliations
Comment

Hepatocyte tPA: where have you been hiding?

Steven L Gonias. Blood. .

Abstract

In this issue of Blood, Zheng et al provide insight into the source of intravascular tissue–type plasminogen activator (tPA). They demonstrate an important role for hepatocytes in determining the basal level of plasma tPA and identify regulatory factors that control tPA expression by hepatocytes.

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Conflict of interest statement

Conflict-of-interest disclosure: The author declares no competing financial interests.

Figures

None
The plasma level of tPA reflects contributions from vascular endothelium and hepatocytes. Hepatocyte expression of tPA is regulated by DACH1 and ATF6.
See this image and copyright information in PMC

Comment on

References

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