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Review
. 2019 Feb;42(1):14-19.
doi: 10.18773/austprescr.2019.002. Epub 2019 Feb 1.

Nitrofurantoin and fosfomycin for resistant urinary tract infections: old drugs for emerging problems

Bradley J Gardiner  1   2   3 , Andrew J Stewardson  1   2   3 , Iain J Abbott  1   2   3 , Anton Y Peleg  1   2   3
Affiliations
Review

Nitrofurantoin and fosfomycin for resistant urinary tract infections: old drugs for emerging problems

Bradley J Gardiner et al. Aust Prescr. 2019 Feb.

Abstract

Uncomplicated urinary tract infection is one of the most common indications for antibiotic use in the community. However, the Gram-negative organisms that can cause the infection are becoming more resistant to antibiotics

Many multidrug resistant organisms retain susceptibility to two old antibiotics, nitrofurantoin and fosfomycin. Advantages over newer drugs include their high urinary concentrations and minimal toxicity

Fosfomycin is a potential treatment option for patients with uncomplicated urinary tract infection due to resistant organisms. Nitrofurantoin may be more effective and can be used for urinary infections in pregnant women

Keywords: antibiotic resistance; fosfomycin; nitrofurantoin; urinary tract infection.

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Comment in

  • Fosfomycin and breastfeeding.
    [No authors listed] [No authors listed] Aust Prescr. 2020 Aug;43(4):113. doi: 10.18773/austprescr.2020.042. Epub 2020 Aug 1. Aust Prescr. 2020. PMID: 32921885 Free PMC article. No abstract available.

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