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. 2018 Dec;18(4):1134-1143.
doi: 10.4314/ahs.v18i4.34.

Influenza virus A (H1 and H3) and B co-circulation among patient presenting with acute respiratory tract infection in Ibadan, Nigeria

Frederick Odun-Ayo  1 , Georgina Odaibo  1 , David Olaleye  1
Affiliations

Influenza virus A (H1 and H3) and B co-circulation among patient presenting with acute respiratory tract infection in Ibadan, Nigeria

Frederick Odun-Ayo et al. Afr Health Sci. 2018 Dec.

Abstract

Background: Influenza is an acute respiratory disease that continues to cause global epidemics and pandemics in human with significant mortality and morbidity.

Objectives: This study was designed to identify the circulating influenza virus in Ibadan, Nigeria during the 2006/2007 season.

Methods: Throat swab samples were collected from patients presenting with acute respiratory tract infection at the Out-Patient Departments of major hospitals in Ibadan over a period of seven months from November 2006 to May 2007. Isolation of influenza virus was performed using Madin-Darby Canine Kidney cell line and 10 days old chicken embryonated egg. Isolates was identified by haemagglutination and haemagglutination-inhibition assays using selected CDC Influenza reference antisera (A, B, subtype H1 and H3).

Results: Out of 128 patients tested, 21(16.4%) yielded positive for virus isolation. Identification of the isolates showed that 19(14.8%) were positive for influenza virus out of which 11(8.6%) and 8(6.2%) were influenza A and B viruses respectively. Influenza A virus 6(4.7%) were subtype H1; 4(3.1%) were co-subtype H1 and H3; and 1(0.8%) was not inhibited by subtype H1 and H3.

Conclusion: The circulation of influenza virus A and B in this study is important to contributing knowledge and data to influenza epidemiology and surveillance in Nigeria.

Keywords: Influenza A; Nigeria; haemagglutination; isolation.

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Figures

Figure 1
Figure 1
Location of the influenza study (indicated in black dot) in Ibadan, South-Western part of Nigeria
See this image and copyright information in PMC

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