Longitudinal changes in HIV DNA in HIV controllers: what do they mean?

Denise C Hsu^{1

2

3}, John W Mellors⁴

Affiliations

¹ Department of Retrovirology, AFRIMS, Bangkok, Thailand.
² US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
³ Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
⁴ Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Comment

Denise C Hsu et al. J Int AIDS Soc. 2019 Feb.

. 2019 Feb;22(2):e25254.

doi: 10.1002/jia2.25254.

Denise C Hsu^{1

2

3}, John W Mellors⁴

¹ Department of Retrovirology, AFRIMS, Bangkok, Thailand.
² US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
³ Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
⁴ Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

No abstract available

Keywords: HIV DNA; HIV controllers; HIV cure; HIV reservoir.

Comment on

Dynamics in HIV-DNA levels over time in HIV controllers.
Avettand-Fenoel V, Bayan T, Gardiennet E, Boufassa F, Lopez P, Lecuroux C, Noel N, Trémeaux P, Monceaux V, Autran B, Meyer L, Saez-Cirion A, Lambotte O, Rouzioux C; CODEX ANRS Cohort Study Group. Avettand-Fenoel V, et al. J Int AIDS Soc. 2019 Jan;22(1):e25221. doi: 10.1002/jia2.25221. J Int AIDS Soc. 2019. PMID: 30629340 Free PMC article.

1. Katlama C, Deeks SG, Autran B, Martinez‐Picado J, van Lunzen J, Rouzioux C, et al. Barriers to a cure for HIV: new ways to target and eradicate HIV‐1 reservoirs. Lancet. 2013;381(9883):2109–17. - PMC - PubMed
1. Ananworanich J, Chomont N, Eller LA, Kroon E, Tovanabutra S, Bose M, et al. HIV DNA set point is rapidly established in acute HIV infection and dramatically reduced by early ART. EBioMedicine. 2016;11:68–72. - PMC - PubMed
1. Strain MC, Little SJ, Daar ES, Havlir DV, Gunthard HF, Lam RY, et al. Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV‐1. J Infect Dis. 2005;191(9):1410–8. - PubMed
1. Hocqueloux L, Avettand‐Fenoel V, Jacquot S, Prazuck T, Legac E, Melard A, et al. Long‐term antiretroviral therapy initiated during primary HIV‐1 infection is key to achieving both low HIV reservoirs and normal T cell counts. J Antimicrob Chemother. 2013;68(5):1169–78. - PubMed
1. Laanani M, Ghosn J, Essat A, Melard A, Seng R, Gousset M, et al. Impact of the timing of initiation of antiretroviral therapy during primary HIV‐1 infection on the decay of cell‐associated HIV‐DNA. Clin Infect Dis. 2015;60(11):1715–21. - PubMed