Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Feb 14;9(2):34.
doi: 10.3390/metabo9020034.

Metabolomics Approaches for the Diagnosis and Understanding of Kidney Diseases

Hayley Abbiss  1   2 , Garth L Maker  3   4 , Robert D Trengove  5   6
Affiliations
Review

Metabolomics Approaches for the Diagnosis and Understanding of Kidney Diseases

Hayley Abbiss et al. Metabolites. .

Abstract

Diseases of the kidney are difficult to diagnose and treat. This review summarises the definition, cause, epidemiology and treatment of some of these diseases including chronic kidney disease, diabetic nephropathy, acute kidney injury, kidney cancer, kidney transplantation and polycystic kidney diseases. Numerous studies have adopted a metabolomics approach to uncover new small molecule biomarkers of kidney diseases to improve specificity and sensitivity of diagnosis and to uncover biochemical mechanisms that may elucidate the cause and progression of these diseases. This work includes a description of mass spectrometry-based metabolomics approaches, including some of the currently available tools, and emphasises findings from metabolomics studies of kidney diseases. We have included a varied selection of studies (disease, model, sample number, analytical platform) and focused on metabolites which were commonly reported as discriminating features between kidney disease and a control. These metabolites are likely to be robust indicators of kidney disease processes, and therefore potential biomarkers, warranting further investigation.

Keywords: acute kidney injury; biomarker; chromatography; chronic kidney disease; diabetic nephropathy; kidney cancer; kidney disease; kidney transplantation; mass spectrometry; metabolomics; polycystic kidney disease.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The overlapping relationships of the described kidney diseases. Chronic kidney disease and sub-entities: Polycystic kidney disease, diabetic nephropathy, kidney cancer and membranous nephropathy may progress to end-stage renal disease requiring transplantation. Reperfusion after transplantation may result in acute kidney injury. Acute kidney injury may also result from sub-entities of CKD.
See this image and copyright information in PMC

References

    1. Moyes C.D., Schulte P.M. Principles of Animal Physiology. 2nd ed. Benjamin Cummings; San Francisco, CA, USA: 2008.
    1. Giebisch G. Kidney, Water and Electrolyte Metabolism. Annu. Rev. Physiol. 1962;24:357–420. doi: 10.1146/annurev.ph.24.030162.002041. - DOI - PubMed
    1. Blantz R.C., Deng A., Miracle C.M., Thomson S.C. Regulation of kidney function and metabolism: A question of supply and demand. Trans. Am. Clin. Climatol. Assoc. 2007;118:23–43. - PMC - PubMed
    1. Gerich J.E. Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: Therapeutic implications. Diabet. Med. 2010;27:136–142. doi: 10.1111/j.1464-5491.2009.02894.x. - DOI - PMC - PubMed
    1. Cass A., Chadban S., Gallagher M., Howard K., Jones A., McDonald S., Snelling P., White S. The Economic Impact of End-Stage Kidney Disease in Australia Projections to 2020. [(accessed on 7 February 2019)]; Available online: https://kidney.org.au/cms_uploads/docs/kha-economic-impact-of-eskd-in-au....

LinkOut - more resources