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Observational Study
. 2019 Feb 15;21(1):61.
doi: 10.1186/s13075-019-1842-x.

Health-related quality of life in systemic sclerosis compared with other rheumatic diseases: a cross-sectional study

Eun Hye Park  1 , Vibeke Strand  2 , Yoon Jeong Oh  3 , Yeong Wook Song  1 , Eun Bong Lee  4
Affiliations
Observational Study

Health-related quality of life in systemic sclerosis compared with other rheumatic diseases: a cross-sectional study

Eun Hye Park et al. Arthritis Res Ther. .

Abstract

Background: Systemic sclerosis (SSc) is a rare autoimmune disease characterized by fibrosis of the skin and the involvement of multiple internal organs. Previous studies reported poorer health-related quality of life (HRQoL) in patients with SSc compared with the general population. However, very little is known about how HRQoL in SSc patients compares with that in patients with other systemic autoimmune diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and Sjogren's syndrome (SjS). Thus, the main aim of this study was to compare HRQoL in SSc patients, patients with other rheumatic diseases, and the general population.

Methods: In this cross-sectional study, patients from the rheumatology clinics of Seoul National University Hospital with SSc, RA, SLE, and SjS were enrolled via a random sampling technique. HRQoL was captured by the Short Form (36) health survey (SF-36), the Short Form Six-Dimensional health index (SF-6D), and the EuroQol Five-Dimensional descriptive system (EQ-5D). Demographic characteristics and standardized disease activity for each disease were also obtained. Previously reported data from 600 healthy Koreans were used for the healthy controls. An ANCOVA test was used to compare the SF-36, SF-6D, and EQ-5D values between study subjects with adjustments for age, sex, disease duration, comorbidities, and disease activity status.

Results: One hundred twenty patients were included in each of the SSc, RA, SLE, and SjS cohorts. Patients with rheumatic diseases had significantly lower SF-36, SF-6D, and EQ-5D scores than healthy controls (all P < 0.001). After statistical adjustments, SSc patients reported significantly lower mental component summary (MCS) scores than patients with RA (P < 0.001) or SLE (P = 0.001). Specifically, the mental health and general health domains were significantly lower in SSc patients than reported in RA or SLE patients (P < 0.001 and P = 0.001, respectively, in both domains). In SSc patients, higher modified Rodnan skin scores (mRSS) correlated with lower MCS scores.

Conclusions: SSc patients report poorer HRQoL than patients with RA or SLE. The extent of skin involvement is associated with poorer HRQoL in SSc patients.

Trial registration: NCT03257878 . Registered 22 August 2017.

Keywords: Disability; Quality of life; Systemic sclerosis.

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Conflict of interest statement

Ethics approval and consent to participate

This study was approved by the institutional review boards and ethics committees at Seoul National University Hospital. All participants provided written informed consent.

Consent for publication

Not applicable

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Comparison of the SF-36 subscales adjusted by age and sex. SF-36, Short Form (36) health survey; SSc, systemic sclerosis; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; SjS, Sjogren’s syndrome; PF, physical function; RP, role–physical; BP, bodily pain; GH, general health perception; VT, vitality; SF, social function; RE, role–emotional; MH, mental health
See this image and copyright information in PMC

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