The unusual SASPects

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Comment

Paulina Strzyz. Nat Rev Mol Cell Biol. 2019 Apr.

. 2019 Apr;20(4):195.

doi: 10.1038/s41580-019-0111-9.

No abstract available

Comment on

Nuclear pore density controls heterochromatin reorganization during senescence.
Boumendil C, Hari P, Olsen KCF, Acosta JC, Bickmore WA. Boumendil C, et al. Genes Dev. 2019 Feb 1;33(3-4):144-149. doi: 10.1101/gad.321117.118. Epub 2019 Jan 28. Genes Dev. 2019. PMID: 30692205 Free PMC article.
L1 drives IFN in senescent cells and promotes age-associated inflammation.
De Cecco M, Ito T, Petrashen AP, Elias AE, Skvir NJ, Criscione SW, Caligiana A, Brocculi G, Adney EM, Boeke JD, Le O, Beauséjour C, Ambati J, Ambati K, Simon M, Seluanov A, Gorbunova V, Slagboom PE, Helfand SL, Neretti N, Sedivy JM. De Cecco M, et al. Nature. 2019 Feb;566(7742):73-78. doi: 10.1038/s41586-018-0784-9. Epub 2019 Feb 6. Nature. 2019. PMID: 30728521 Free PMC article.
Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence.
Sen P, Lan Y, Li CY, Sidoli S, Donahue G, Dou Z, Frederick B, Chen Q, Luense LJ, Garcia BA, Dang W, Johnson FB, Adams PD, Schultz DC, Berger SL. Sen P, et al. Mol Cell. 2019 Feb 21;73(4):684-698.e8. doi: 10.1016/j.molcel.2019.01.021. Epub 2019 Feb 14. Mol Cell. 2019. PMID: 30773298 Free PMC article.

1. Boumendil, C. et al. Nuclear pore density controls heterochromatin reorganization during senescence. Genes Dev. 33, 144–149 (2019) - DOI
1. De Cecco, M. et al. L1 drives IFN in senescent cells and promotes age-associated inflammation. Nature 566, 73–78 (2019) - DOI
1. Sen, P. et al. Histone acetyltransferase p300 induces de novo super-enhancers to drive cellular senescence. Mol. Cell https://doi.org/10.1016/j.molcel.2019.01.021 (2019) - DOI - PubMed