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Review
. 2019 Mar;46(1):1-17.
doi: 10.1016/j.clp.2018.10.001. Epub 2018 Dec 12.

Biomarker Discovery and Utility in Necrotizing Enterocolitis

Gregory P Goldstein  1 , Karl G Sylvester  2
Affiliations
Review

Biomarker Discovery and Utility in Necrotizing Enterocolitis

Gregory P Goldstein et al. Clin Perinatol. 2019 Mar.

Abstract

Necrotizing enterocolitis (NEC) is a devastating disease of prematurity, with no current method for early diagnosis. Diagnosis is particularly challenging, frequently occurring after the disease has progressed to the point of significant and often irreversible intestinal damage. Biomarker research has tremendous potential to advance clinical management of NEC and our understanding of its pathogenesis. This review discusses the need for novel biomarkers in NEC management, evaluates studies investigating such biomarkers, and explains the difficulties associated with translating biomarker discovery into clinical use.

Keywords: Biomarker; Biomarker discovery; Diagnosis; Necrotizing enterocolitis; Pathogenesis.

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