[Hemolytic disorders and venous thrombosis: An update]

Abstract

Many factors can contribute to the risk of venous thrombosis observed in hemolytic diseases. Some mechanisms are related to hemolysis by itself, while others seem more specific to each disease. Despite recent advances in the quantification of this risk and in understanding its physiopathology, the association of hemolysis with venous thrombosis is often unknown. The purpose of this general review is to clarify the main pro-thrombotic mechanisms during hemolysis and to synthesize the clinical data currently available. We will focus on the main types of hemolytic pathologies encountered in current practice, namely paroxysmal nocturnal hemoglobinuria, hemoglobinopathies, auto-immune hemolytic anemia and thrombotic microangiopathies.

Keywords: Anémie hémolytique auto-immune; Auto-immune hemolytic anemia; Hemoglobinopathies; Hemolysis; Hémoglobinopathies; Hémoglobinurie paroxystique nocturne; Hémolyse; Paroxysmal nocturnal hemoglobinuria; Thrombose veineuse; Venous thrombosis.