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. 2019 Jan 29:11:1081-1085.
doi: 10.2147/CMAR.S192788. eCollection 2019.

Oncologic outcome of parotid mucoepidermoid carcinoma in pediatric patients

Qigen Fang  1 , Fei Liu  2 , Dongjie Seng  3
Affiliations

Oncologic outcome of parotid mucoepidermoid carcinoma in pediatric patients

Qigen Fang et al. Cancer Manag Res. .

Abstract

Background: The goal of this study was to investigate the long-term oncologic outcome of parotid mucoepidermoid carcinoma (MEC) in pediatric patients.

Patients and methods: Patients <19 years old who were diagnosed with MEC from January 1990 to December 2017 were retrospectively enrolled in this study. The main analyzed indexes included intraparotid node (IPN) metastasis, neutrophil-tolymphocyte ratio (NLR), loco-regional control (LRC), and disease-specific survival (DSS) rates.

Results: A total of 73 patients were enrolled. IPN metastasis occurred in 13 (17.8%) patients; the mean value of the NLR was 2.48 (range: 1.3-6.1). Loco-regional recurrence occurred in 12 patients, and 7 patients died of the disease. The 10-year LRC and DSS rates were 83% and 88%, respectively. IPN metastasis remained significantly related to recurrence in both univariate and Cox model analyses; a high NLR was significantly associated with recurrence in the univariate analysis but not in the Cox model. IPN metastasis remained significantly related to disease-related death in both the univariate and Cox model analyses; a high NLR was not associated with the DSS in univariate analysis.

Conclusion: The long-term survival rate was relatively favorable in pediatric MEC. IPN metastasis was an independent risk factor for loco-regional recurrence and DSS. The role of the NLR in predicting survival in parotid cancer requires more research.

Keywords: mucoepidermoid carcinoma; parotid cancer; pediatric cancer; salivary cancer.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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