This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

Editorial

. 2019 Jan 18;10(6):622-623.

doi: 10.18632/oncotarget.26593.

Role of transcription-regulating kinase CDK8 in colon cancer metastasis

Jiaxin Liang¹, Mengqian Chen¹, Eugenia V Broude¹, Igor B Roninson¹

Affiliations

Affiliation

¹ Department of Drug Discovery and Biomedical Sciences, University of South Carolina, Columbia, SC, USA; Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russian Federation.

PMID: 30774756
PMCID: PMC6363006
DOI: 10.18632/oncotarget.26593

Editorial

Role of transcription-regulating kinase CDK8 in colon cancer metastasis

Jiaxin Liang et al. Oncotarget. 2019.

. 2019 Jan 18;10(6):622-623.

doi: 10.18632/oncotarget.26593.

Authors

Jiaxin Liang¹, Mengqian Chen¹, Eugenia V Broude¹, Igor B Roninson¹

Affiliation

¹ Department of Drug Discovery and Biomedical Sciences, University of South Carolina, Columbia, SC, USA; Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russian Federation.

PMID: 30774756
PMCID: PMC6363006
DOI: 10.18632/oncotarget.26593

No abstract available

Keywords: CDK8; TIMP3; colon cancer; liver; metastasis.

PubMed Disclaimer

Figures

Figure 1. Mechanism of the effect of CDK8 on metastatic growth of colon cancer in the liver

See this image and copyright information in PMC

Similar articles

Retroviral cyclin controls cyclin-dependent kinase 8-mediated transcription elongation and reinitiation.
Birkenheuer CH, Brewster CD, Quackenbush SL, Rovnak J. Birkenheuer CH, et al. J Virol. 2015 May;89(10):5450-61. doi: 10.1128/JVI.00464-15. Epub 2015 Mar 4. J Virol. 2015. PMID: 25741012 Free PMC article.
Role of CDK8 and beta-catenin in colorectal adenocarcinoma.
Seo JO, Han SI, Lim SC. Seo JO, et al. Oncol Rep. 2010 Jul;24(1):285-91. Oncol Rep. 2010. PMID: 20514474
Downregulation of CDK-8 inhibits colon cancer hepatic metastasis by regulating Wnt/β-catenin pathway.
Cai WS, Shen F, Feng Z, Chen JW, Liu QC, Li EM, Xu B, Cao J. Cai WS, et al. Biomed Pharmacother. 2015 Aug;74:153-7. doi: 10.1016/j.biopha.2015.08.015. Epub 2015 Aug 15. Biomed Pharmacother. 2015. PMID: 26349978
CDK8 kinase--An emerging target in targeted cancer therapy.
Rzymski T, Mikula M, Wiklik K, Brzózka K. Rzymski T, et al. Biochim Biophys Acta. 2015 Oct;1854(10 Pt B):1617-29. doi: 10.1016/j.bbapap.2015.05.011. Epub 2015 May 22. Biochim Biophys Acta. 2015. PMID: 26006748 Review.
The two faces of Cdk8, a positive/negative regulator of transcription.
Nemet J, Jelicic B, Rubelj I, Sopta M. Nemet J, et al. Biochimie. 2014 Feb;97:22-7. doi: 10.1016/j.biochi.2013.10.004. Epub 2013 Oct 15. Biochimie. 2014. PMID: 24139904 Review.

See all similar articles

Cited by

A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched Pharmacokinetics.
Zhang L, Cheng C, Li J, Wang L, Chumanevich AA, Porter DC, Mindich A, Gorbunova S, Roninson IB, Chen M, McInnes C. Zhang L, et al. J Med Chem. 2022 Feb 24;65(4):3420-3433. doi: 10.1021/acs.jmedchem.1c01951. Epub 2022 Feb 3. J Med Chem. 2022. PMID: 35114084 Free PMC article.
Propagated Circulating Tumor Cells Uncover the Potential Role of NFκB, EMT, and TGFβ Signaling Pathways and COP1 in Metastasis.
Xiao J, Sharma U, Arab A, Miglani S, Bhalla S, Suguru S, Suter R, Mukherji R, Lippman ME, Pohlmann PR, Zeck JC, Marshall JL, Weinberg BA, He AR, Noel MS, Schlegel R, Goodarzi H, Agarwal S. Xiao J, et al. Cancers (Basel). 2023 Mar 17;15(6):1831. doi: 10.3390/cancers15061831. Cancers (Basel). 2023. PMID: 36980717 Free PMC article.
Mediator kinase module proteins, genetic alterations and expression of super-enhancer regulated genes in colorectal cancer.
Voutsadakis IA. Voutsadakis IA. Pharmacol Rep. 2024 Jun;76(3):535-556. doi: 10.1007/s43440-024-00589-2. Epub 2024 Apr 11. Pharmacol Rep. 2024. PMID: 38602606
miR‑592 acts as an oncogene and promotes medullary thyroid cancer tumorigenesis by targeting cyclin‑dependent kinase 8.
Liu T, Meng J, Zhang Y. Liu T, et al. Mol Med Rep. 2020 Oct;22(4):3316-3326. doi: 10.3892/mmr.2020.11392. Epub 2020 Jul 30. Mol Med Rep. 2020. PMID: 32945439 Free PMC article.
MicroRNAs in Medullary Thyroid Carcinoma: A State of the Art Review of the Regulatory Mechanisms and Future Perspectives.
Galuppini F, Censi S, Moro M, Carraro S, Sbaraglia M, Iacobone M, Fassan M, Mian C, Pennelli G. Galuppini F, et al. Cells. 2021 Apr 20;10(4):955. doi: 10.3390/cells10040955. Cells. 2021. PMID: 33924120 Free PMC article. Review.

References

1. Firestein R, et al. Nature. 2008;455:547–51. - PMC - PubMed
1. Galbraith MD, et al. Cell. 2013;153:1327–39. - PMC - PubMed
1. Alarcon C, et al. Cell. 2009;139:757–69. - PMC - PubMed
1. McDermott MS, et al. Oncotarget. 2017;8:12558–75. doi: 10.18632/oncotarget.14894. - DOI - PMC - PubMed
1. Chen M, et al. Proc Natl Acad Sci U S A. 2017;114:10208–13. - PMC - PubMed

Publication types

Actions

Grants and funding

LinkOut - more resources

Full Text Sources