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Editorial
. 2019 Jan 18;10(6):629-630.
doi: 10.18632/oncotarget.26602.

AEG-1 targeting for inhibiting inflammation: potential anti-HCC strategy

Saranya Chidambaranathan Reghupaty  1 , Rachel Mendoza  1 , Devanand Sarkar  1
Affiliations
Editorial

AEG-1 targeting for inhibiting inflammation: potential anti-HCC strategy

Saranya Chidambaranathan Reghupaty et al. Oncotarget. .
No abstract available

Keywords: AEG-1; HCC; NF-kappaB; inflammation; macrophages.

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Figures

Figure 1
Figure 1. Cartoon showing the mechanism by which AEG-1 regulates the inflammatory process and HCC development
Left panel. In Wild-type (WT) mice injury to hepatocytes activates NF-κB and IL-1 production that activates NF-κB and IL-6 production in the macrophages. IL-6 activates oncogenic STAT3 in hepatocytes facilitating transformation and development of HCC. Right panel. In the absence of AEG-1 (AEG-1KO), NF-κB activation is inhibited in hepatocytes and macrophages, thereby abrogating the inflammatory signaling and HCC development. Adapted from Reference 2.
See this image and copyright information in PMC

References

    1. Sarkar D, et al. Adv Cancer Res. 2013;120:193–221. - PMC - PubMed
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    1. Rajasekaran D, et al. Bioconjug Chem. 2015;26:1651–61. - PMC - PubMed
    1. Sarkar D, et al. Cancer Res. 2008;68:1478–84. - PubMed
    1. Pikarsky E, et al. Nature. 2004;431:461–6. - PubMed

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