Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Mar;2(1):20-24.
doi: 10.1016/j.afos.2016.02.001. Epub 2016 Mar 3.

Type 2 diabetes mellitus and bone fragility: Special focus on bone imaging

Yong Jun Choi  1 , Yoon-Sok Chung  1
Affiliations
Review

Type 2 diabetes mellitus and bone fragility: Special focus on bone imaging

Yong Jun Choi et al. Osteoporos Sarcopenia. 2016 Mar.

Abstract

Fragility fracture rate is increased in type 2 diabetes patients despite of higher bone mineral density than non-diabetes control subjects. Vertebral fractures are usually asymptomatic; therefore, morphometric radiologic evaluation should be considered especially for diabetes patients. Bone quality may more contribute to the increased risk of osteoporotic fractures in patients with type 2 diabetes than bone mass. Hip geometry, cortical porosity, and trabecular bone score have been studied as bone quality parameters by imaging in type 2 diabetes mellitus.

Keywords: Cortical porosity; Hip geometry; Trabecular bone score; Vertebral fracture assessment.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Type 2 diabetes mellitus with low bone quality resulted in increased risk of fragility fractures, special focus on bone imaging.
Fig. 2
Fig. 2
Quantitative morphometric vertebral fracture assessment method.
Fig. 3
Fig. 3
Hip geometry parameters including cross sectional area and section modulus.
Fig. 4
Fig. 4
Trabecular bone score assessed with software in lumbar spine.
See this image and copyright information in PMC

References

    1. Choi Y.J., Kim D.J., Lee Y., Chung Y.-S. Insulin is inversely associated with bone mass especially in the insulin-resistant population: the Korea and US National Health and Nutrition Examination Surveys. J Clin Endocrinol Metab. 2014;99:1433–1441. - PubMed
    1. Kim J.H., Choi H.J., Ku E.J., Kim K.M., Kim S.W., Cho N.H. Trabecular bone score as an indicator for skeletal deterioration in diabetes. J Clin Endocrinol Metab. 2015;100:475–482. - PubMed
    1. Srikanthan P., Crandall C.J., Miller-Martinez D., Seeman T.E., Greendale G.A., Binkley N. Insulin resistance and bone strength: findings from the study of midlife in the United States. J Bone Min Res. 2014;29:796–803. - PMC - PubMed
    1. de Liefde I.I., van der Klift M., de Laet C.E., van Daele P.L., Hofman A., Pols H.A. Bone mineral density and fracture risk in type-2 diabetes mellitus: the Rotterdam Study. Osteoporos Int. 2005;16:1713–1720. - PubMed
    1. Strotmeyer E.S., Cauley J.A., Schwartz A.V., Nevitt M.C., Resnick H.E., Bauer D.C. Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the health, aging, and body composition study. Arch Intern Med. 2005;165:1612–1617. - PubMed

LinkOut - more resources