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Multicenter Study
. 2019 Oct;51(4):1285-1294.
doi: 10.4143/crt.2018.464. Epub 2019 Feb 19.

Development of Protocol for Korean Lung Cancer Screening Project (K-LUCAS) to Evaluate Effectiveness and Feasibility to Implement National Cancer Screening Program

Jaeho Lee  1 , Juntae Lim  1   2 , Yeol Kim  1   2 , Hyae Young Kim  3 , Jin Mo Goo  4 , Choon-Taek Lee  5 , Seung Hun Jang  6 , Won-Chul Lee  7 , Chan Wha Lee  3 , Jin Young An  8 , Ki Dong Ko  9 , Min Ki Lee  10 , Kui Son Choi  1   2 , Boyoung Park  1   2 , Duk Hyoung Lee  1
Affiliations
Multicenter Study

Development of Protocol for Korean Lung Cancer Screening Project (K-LUCAS) to Evaluate Effectiveness and Feasibility to Implement National Cancer Screening Program

Jaeho Lee et al. Cancer Res Treat. 2019 Oct.

Abstract

Purpose: To reduce lung cancer mortality, lung cancer screening was recommended using low-dose computed tomography (LDCT) to high-risk population. A protocol for multicenter lung cancer screening pilot project was developed to evaluate the effectiveness and feasibility of lung cancer screening to implement National Cancer Screening Program in Korea.

Materials and methods: Multidisciplinary expert committee was comprised to develop a standardized protocol for Korean Lung Cancer Screening Project (K-LUCAS). K-LUCAS is a population-based single arm trial that targets high-risk population aged 55-74 years with at least 30 pack-year smoking history. LDCT results are reported by Lung-RADS suggested by American Radiology Society. Network-based system using computer-aided detection program is prepared to assist reducing diagnostic errors. Smoking cessation counselling is provided to all currently smoking participants. A small pilot test was conducted to check the feasibility and compliance of the protocols for K-LUCAS.

Results: In pilot test, 256 were participated. The average age of participants was 63.2 years and only three participants (1.2%) were female. The participants had a smoking history of 40.5 pack-year on average and 53.9% were current smokers. Among them, 86.3% had willing to participate in lung cancer screening again. The average willingness to quit smoking among current smokers was 12.7% higher than before screening. In Lung-RADS reports, 10 (3.9%) were grade 3 and nine (3.5%) were grade 4. One participant was diagnosed as lung cancer.

Conclusion: The protocol developed by this study is assessed to be feasible to perform K-LUCAS in multicenter nationwide scale.

Keywords: Low-dose computed tomography; Lung neoplasms; Mass screening; Pilot test; Smokers.

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Conflict of interest statement

Conflict of interest relevant to this article was not reported.

Figures

Fig. 1.
Fig. 1.
A summary of lung cancer screening procedure in Korean Lung Cancer Screening Project (K-LUCAS). (A) A summary of lung cancer screening procedure for National Cancer Screening Program (NCSP) participants. (B) A summary of lung cancer screening procedure for smoking cessation clinic visitors. LDCT, low-dose computed tomography.
Fig. 2.
Fig. 2.
Network-based diagnosis supporting system using computer-aided detection (CAD) program in Korean Lung Cancer Screening Project (K-LUCAS). CT, computed tomography.
Fig. 3.
Fig. 3.
Participant flow to screening in pilot test. K-LUCAS, Korean Lung Cancer Screening Project.
Fig. 4.
Fig. 4.
Anxiety of lung cancer before and after lung cancer screening.
See this image and copyright information in PMC

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