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Review
. 2019 Aug;54(8):1179-1188.
doi: 10.1038/s41409-019-0476-6. Epub 2019 Feb 18.

"Worldwide Network for Blood & Marrow Transplantation (WBMT) special article, challenges facing emerging alternate donor registries"

Mahmoud Aljurf  1 , Daniel Weisdorf  2 , Feras Alfraih  3 , Jeff Szer  4 , Carlheinz Müller  5 , Dennis Confer  6 , Shahrukh Hashmi  1 , Nicolaus Kröger  7 , Bronwen E Shaw  8 , Hildegard Greinix  9 , Mohamed A Kharfan-Dabaja  10 , Lydia Foeken  11 , Adriana Seber  12 , Syed Ahmed  1 , Areej El-Jawahri  13 , Moheeb Al-Awwami  1 , Yoshiko Atsuta  14 , Marcelo Pasquini  8 , Amr Hanbali  1 , Hazzaa Alzahrani  1 , Shinichiro Okamoto  15 , Eliane Gluckman  16   17 , Mohamad Mohty  18 , Yoshihisa Kodera  19 , Mary Horowitz  8 , Dietger Niederwieser  20   21 , Riad El Fakih  22
Affiliations
Review

"Worldwide Network for Blood & Marrow Transplantation (WBMT) special article, challenges facing emerging alternate donor registries"

Mahmoud Aljurf et al. Bone Marrow Transplant. 2019 Aug.

Abstract

Hematopoietic cell transplantation (HCT) activity is increasing at an unprecedented pace with > 50,000 allogeneic transplants occurring annually worldwide. Establishing a functional HCT donor registry can be very challenging with respect to ethnicities, financial, technical, and geopolitical issues. Extensive planning steps are essential to overcome the expected challenges while establishing the registry, and to maintain its functionality. A few strategies can help move past those challenges and push the development of such registries forward. Authorities involved in HCT donor registry establishment will have to balance the advantages and costs of such a project and accommodate the emerging alternatives such as cord blood or related haploidentical transplants. Miscalculations and incomplete understanding of the various aspects of the process can have tremendous impact on the optimization of a HCT donor registry especially in developing countries. Herein we present some challenges in establishing such a registry and present potential solutions.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Expected cancer mortality rates in 2020
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Fig. 2
Projected population growth by country 2005–2050
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Fig. 3
Age distribution in developing versus developed countries
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Fig. 4
Location of unrelated donor registries worldwide
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Fig. 5
Probability to find a 10/10, 9/10, and 8/10 match in Saudi Arabia
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Fig. 6
Changes in donor choice 2006–2015
See this image and copyright information in PMC

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