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. 2019 Feb 18;9(1):31.
doi: 10.1186/s13613-019-0502-2.

Invasive pulmonary aspergillosis in cirrhotic patients: analysis of a 10-year clinical experience

Eric Levesque  1   2 , Nawel Ait-Ammar  3   4 , Daniela Dudau  5 , Noémie Clavieras  5 , Cyrille Feray  6 , Françoise Foulet  4 , Françoise Botterel  3   4
Affiliations

Invasive pulmonary aspergillosis in cirrhotic patients: analysis of a 10-year clinical experience

Eric Levesque et al. Ann Intensive Care. .

Abstract

Background: Cirrhosis is not recognised as one of the main risk factors of invasive pulmonary aspergillosis (IPA), although its prevalence is increasing. The aim of our study was to identify factors for IPA in such patients with a positive Aspergillus sp. culture in respiratory samples and to evaluate its impact on outcome.

Methods: We conducted a monocentric retrospective study between January 2005 and December 2015. All cirrhotic patients hospitalised in our liver ICU with a positive Aspergillus sp. respiratory sample were included. These patients were case-matched with cirrhotic patients without positive Aspergillus respiratory sample. Finally, the patients were classified as having putative aspergillosis or colonisation according to the criteria described previously.

Results: In total, 986 cirrhotic patients were admitted to ICU during the study period. Among these, sixty patients had a positive Aspergillus sp. respiratory sample. Chronic obstructive pulmonary disease (COPD) comorbidity and organ supports were significantly associated with Aspergillus colonisation. Seventeen patients (28%) were diagnosed as proven or putative IPA and 43 were considered as colonised by Aspergillus sp. The median delay between ICU admission and an IPA diagnosis was 2 [2-24] days. Only COPD was predictive of the presence of IPA (OR 6.44; 95% CI 1.43-28.92; p = 0.0151) in patients with a positive Aspergillus sp. culture. The probability of in-hospital mortality was 71% in the IPA group versus 19% in the colonisation group (p = 0.0001).

Conclusion: Patients with cirrhosis can be at risk of IPA, especially with COPD. Antifungal agents should be given as soon as possible mainly in cirrhotic patients with COPD.

Keywords: Aspergillus; Cirrhosis; Immunosuppression; Intensive care unit; Invasive pulmonary aspergillosis.

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Figures

Fig. 1
Fig. 1
Individual cases of invasive pulmonary aspergillosis (solid bars) and Aspergillus spp. colonisation (open bars) reported from 2005 to 2015 (n = 60)
Fig. 2
Fig. 2
Kaplan–Meier survival curve of 17 cirrhotic patients with IPA and 43 patients with Aspergillus spp. colonisation. Curves were compared using log-rank test
See this image and copyright information in PMC

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